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Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.

LA Breckler, J Hale, A Taylor, JA Dunstan, CA Thornton, SL Prescott, Cathy Thornton Orcid Logo

Allergy, Volume: 63, Issue: 11, Pages: 1473 - 1480

Swansea University Author: Cathy Thornton Orcid Logo

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DOI (Published version): 10.1111/j.1398-9995.2008.01718.x.

Abstract

BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study...

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Published in: Allergy
ISSN: 1398-9995
Published: Wiley 2008
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URI: https://cronfa.swan.ac.uk/Record/cronfa9994
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2013-09-21T21:19:14.0025817</datestamp><bib-version>v2</bib-version><id>9994</id><entry>2012-03-21</entry><title>Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.</title><swanseaauthors><author><sid>c71a7a4be7361094d046d312202bce0c</sid><ORCID>0000-0002-5153-573X</ORCID><firstname>Cathy</firstname><surname>Thornton</surname><name>Cathy Thornton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-03-21</date><deptcode>BMS</deptcode><abstract>BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study, peripheral blood was collected from allergic (n = 69) and nonallergic (n = 63) pregnant women at 20, 30, 36-week gestation and 6-week postpartum (pp). Cord blood was collected at delivery. Mixed lymphocyte reactions were used to measure maternal cytokine responses [interleukin-6 (IL-6), IL-10, IL-13 and (interferon-gamma) IFN-gamma] at each time point towards foetal mononuclear cells.RESULTS: Maternal cytokine responses during pregnancy (20, 30 and 36 weeks) were suppressed compared to the responses at 6-week pp. The ratio of maternal IFN-gamma/IL-13 and IFN-gamma/IL-10 responses were lower during pregnancy. Allergic mothers had lower IFN-gamma responses at each time-point during pregnancy with the greatest difference in responses observed at 36-week gestation. When allergic and nonallergic women were further stratified by gravidity group, IFN-gamma responses of allergic multigravid mothers were significantly lower than nonallergic multigravid mothers during pregnancy.CONCLUSIONS: During normal pregnancy, peripheral T-cell cytokine responses to foetal alloantigens may be altered by both allergic status of the mother and previous pregnancies. These factors could influence the cytokine milieu experienced by the foetus and will be further explored in the development of allergic disease during early life</abstract><type>Journal Article</type><journal>Allergy</journal><volume>63</volume><journalNumber>11</journalNumber><paginationStart>1473</paginationStart><paginationEnd>1480</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><issnPrint>1398-9995</issnPrint><issnElectronic/><keywords>allergy; alloimmune response; maternal&#x2013;foetal interaction; pregnancy; T helper</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2008</publishedYear><publishedDate>2008-12-31</publishedDate><doi>10.1111/j.1398-9995.2008.01718.x.</doi><url>http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01718.x/pdf</url><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2013-09-21T21:19:14.0025817</lastEdited><Created>2012-03-21T16:17:16.0000000</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>LA</firstname><surname>Breckler</surname><order>1</order></author><author><firstname>J</firstname><surname>Hale</surname><order>2</order></author><author><firstname>A</firstname><surname>Taylor</surname><order>3</order></author><author><firstname>JA</firstname><surname>Dunstan</surname><order>4</order></author><author><firstname>CA</firstname><surname>Thornton</surname><order>5</order></author><author><firstname>SL</firstname><surname>Prescott</surname><order>6</order></author><author><firstname>Cathy</firstname><surname>Thornton</surname><orcid>0000-0002-5153-573X</orcid><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2013-09-21T21:19:14.0025817 v2 9994 2012-03-21 Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status. c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2012-03-21 BMS BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study, peripheral blood was collected from allergic (n = 69) and nonallergic (n = 63) pregnant women at 20, 30, 36-week gestation and 6-week postpartum (pp). Cord blood was collected at delivery. Mixed lymphocyte reactions were used to measure maternal cytokine responses [interleukin-6 (IL-6), IL-10, IL-13 and (interferon-gamma) IFN-gamma] at each time point towards foetal mononuclear cells.RESULTS: Maternal cytokine responses during pregnancy (20, 30 and 36 weeks) were suppressed compared to the responses at 6-week pp. The ratio of maternal IFN-gamma/IL-13 and IFN-gamma/IL-10 responses were lower during pregnancy. Allergic mothers had lower IFN-gamma responses at each time-point during pregnancy with the greatest difference in responses observed at 36-week gestation. When allergic and nonallergic women were further stratified by gravidity group, IFN-gamma responses of allergic multigravid mothers were significantly lower than nonallergic multigravid mothers during pregnancy.CONCLUSIONS: During normal pregnancy, peripheral T-cell cytokine responses to foetal alloantigens may be altered by both allergic status of the mother and previous pregnancies. These factors could influence the cytokine milieu experienced by the foetus and will be further explored in the development of allergic disease during early life Journal Article Allergy 63 11 1473 1480 Wiley 1398-9995 allergy; alloimmune response; maternal–foetal interaction; pregnancy; T helper 31 12 2008 2008-12-31 10.1111/j.1398-9995.2008.01718.x. http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01718.x/pdf COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2013-09-21T21:19:14.0025817 2012-03-21T16:17:16.0000000 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine LA Breckler 1 J Hale 2 A Taylor 3 JA Dunstan 4 CA Thornton 5 SL Prescott 6 Cathy Thornton 0000-0002-5153-573X 7
title Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
spellingShingle Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
Cathy Thornton
title_short Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
title_full Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
title_fullStr Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
title_full_unstemmed Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
title_sort Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
author_id_str_mv c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
author Cathy Thornton
author2 LA Breckler
J Hale
A Taylor
JA Dunstan
CA Thornton
SL Prescott
Cathy Thornton
format Journal article
container_title Allergy
container_volume 63
container_issue 11
container_start_page 1473
publishDate 2008
institution Swansea University
issn 1398-9995
doi_str_mv 10.1111/j.1398-9995.2008.01718.x.
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01718.x/pdf
document_store_str 0
active_str 0
description BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study, peripheral blood was collected from allergic (n = 69) and nonallergic (n = 63) pregnant women at 20, 30, 36-week gestation and 6-week postpartum (pp). Cord blood was collected at delivery. Mixed lymphocyte reactions were used to measure maternal cytokine responses [interleukin-6 (IL-6), IL-10, IL-13 and (interferon-gamma) IFN-gamma] at each time point towards foetal mononuclear cells.RESULTS: Maternal cytokine responses during pregnancy (20, 30 and 36 weeks) were suppressed compared to the responses at 6-week pp. The ratio of maternal IFN-gamma/IL-13 and IFN-gamma/IL-10 responses were lower during pregnancy. Allergic mothers had lower IFN-gamma responses at each time-point during pregnancy with the greatest difference in responses observed at 36-week gestation. When allergic and nonallergic women were further stratified by gravidity group, IFN-gamma responses of allergic multigravid mothers were significantly lower than nonallergic multigravid mothers during pregnancy.CONCLUSIONS: During normal pregnancy, peripheral T-cell cytokine responses to foetal alloantigens may be altered by both allergic status of the mother and previous pregnancies. These factors could influence the cytokine milieu experienced by the foetus and will be further explored in the development of allergic disease during early life
published_date 2008-12-31T03:11:29Z
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score 11.013148

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