Journal article 873 views 130 downloads
Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
,
Nick Jones ,
Cathy Thornton
Immunometabolism, Volume: 3, Issue: 4, Start page: e210031
Swansea University Authors:
Benjamin Jenkins, April Rees , Nick Jones , Cathy Thornton
-
PDF | Version of Record
Copyright © 2021 by the author(s). Licensee Hapres, London, United Kingdom. This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License.
Download (4.15MB)
DOI (Published version): 10.20900/immunometab20210031
Abstract
Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are th...
| Published in: | Immunometabolism |
|---|---|
| ISSN: | 2084-6835 2633-0407 |
| Published: |
Hapres
2021
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa58734 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract: |
Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy. |
|---|---|
| Keywords: |
immunometabolism, maternal metabolism, pregnancy, Treg, Th2 |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Swansea University Research Excellence Scholarship; Ser Cymru II, Welsh Government and MRC (MR/V037013) |
| Issue: |
4 |
| Start Page: |
e210031 |