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Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?

Benjamin Jenkins, April Rees Orcid Logo, Nick Jones Orcid Logo, Cathy Thornton Orcid Logo

Immunometabolism, Volume: 3, Issue: 4, Start page: e210031

Swansea University Authors: Benjamin Jenkins, April Rees Orcid Logo, Nick Jones Orcid Logo, Cathy Thornton Orcid Logo

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DOI (Published version): 10.20900/immunometab20210031

Abstract

Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are th...

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Published in: Immunometabolism
ISSN: 2084-6835 2633-0407
Published: Hapres 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58734
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first_indexed 2021-11-22T11:21:56Z
last_indexed 2021-12-07T04:15:38Z
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spelling 2021-12-06T17:28:21.1877447 v2 58734 2021-11-22 Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy? 90f7cfd66781feba615436189178a528 Benjamin Jenkins Benjamin Jenkins true false ae088f7f8609d2b2ea4666f9b52b3c15 0000-0002-4408-634X April Rees April Rees true false 0fce0f7ddbdbfeb968f4e2f1e3f86744 0000-0003-4846-5117 Nick Jones Nick Jones true false c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2021-11-22 BMS Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy. Journal Article Immunometabolism 3 4 e210031 Hapres 2084-6835 2633-0407 immunometabolism, maternal metabolism, pregnancy, Treg, Th2 4 10 2021 2021-10-04 10.20900/immunometab20210031 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Swansea University Research Excellence Scholarship; Ser Cymru II, Welsh Government and MRC (MR/V037013) 2021-12-06T17:28:21.1877447 2021-11-22T11:17:35.7416562 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Benjamin Jenkins 1 April Rees 0000-0002-4408-634X 2 Nick Jones 0000-0003-4846-5117 3 Cathy Thornton 0000-0002-5153-573X 4 58734__21621__b350fed5ef504eea8be4e74df3f30498.pdf 58734.pdf 2021-11-22T11:21:07.6088785 Output 4350515 application/pdf Version of Record true Copyright © 2021 by the author(s). Licensee Hapres, London, United Kingdom. This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License. true eng https://creativecommons.org/licenses/by/4.0/
title Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
spellingShingle Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
Benjamin Jenkins
April Rees
Nick Jones
Cathy Thornton
title_short Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
title_full Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
title_fullStr Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
title_full_unstemmed Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
title_sort Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
author_id_str_mv 90f7cfd66781feba615436189178a528
ae088f7f8609d2b2ea4666f9b52b3c15
0fce0f7ddbdbfeb968f4e2f1e3f86744
c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv 90f7cfd66781feba615436189178a528_***_Benjamin Jenkins
ae088f7f8609d2b2ea4666f9b52b3c15_***_April Rees
0fce0f7ddbdbfeb968f4e2f1e3f86744_***_Nick Jones
c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
author Benjamin Jenkins
April Rees
Nick Jones
Cathy Thornton
author2 Benjamin Jenkins
April Rees
Nick Jones
Cathy Thornton
format Journal article
container_title Immunometabolism
container_volume 3
container_issue 4
container_start_page e210031
publishDate 2021
institution Swansea University
issn 2084-6835
2633-0407
doi_str_mv 10.20900/immunometab20210031
publisher Hapres
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy.
published_date 2021-10-04T04:15:30Z
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