Journal article 343 views 55 downloads
Immunometabolic adaptation in monocytes underpins functional changes during pregnancy
,
Benjamin Jenkins,
Roberto Angelini ,
Luke Davies ,
James Cronin ,
Nick Jones ,
Cathy Thornton
iScience, Volume: 27, Issue: 5, Start page: 109779
Swansea University Authors:
April Rees , Benjamin Jenkins, Roberto Angelini , Luke Davies , James Cronin , Nick Jones , Cathy Thornton
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Copyright: 2024 The Author(s). This is an open access article under the CC BY license.
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DOI (Published version): 10.1016/j.isci.2024.109779
Abstract
Metabolic heterogeneity is a determinant of immune cell function. The normal physiological metabolic reprogramming of pregnancy that ensures the fuel requirements of mother and baby are met, might also underpin changes in immunity that occur with pregnancy and manifest as altered responses to pathog...
| Published in: | iScience |
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| ISSN: | 2589-0042 |
| Published: |
Elsevier BV
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa66076 |
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| Abstract: |
Metabolic heterogeneity is a determinant of immune cell function. The normal physiological metabolic reprogramming of pregnancy that ensures the fuel requirements of mother and baby are met, might also underpin changes in immunity that occur with pregnancy and manifest as altered responses to pathogens and changes to autoimmune disease symptoms. Using peripheral blood from pregnant women at term, we reveal that monocytes lose M2-like and gain M1-like properties accompanied by reductions in mitochondrial mass, maximal respiration and cardiolipin content in pregnancy; glycolysis is unperturbed. We establish that muramyl dipeptide (MDP)-stimulated cytokine production relies on oxidative metabolism, then show in pregnancy reduced cytokine production in response to MDP but not LPS. Overall, mitochondrially centred metabolic capabilities of late gestation monocytes are downregulated revealing natural plasticity in monocyte phenotype and function that could reveal targets for improving pregnancy outcomes but also yield alternative therapeutic approaches to diverse metabolic and/or immune-mediated diseases beyond pregnancy. |
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| Keywords: |
Reproductive medicine; Physiology; Immunology; cell biology |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Research Wales Innovation Fund (RWIF) of the Higher Education Funding Council Wales (HEFCW) |
| Issue: |
5 |
| Start Page: |
109779 |