Journal article 1542 views
Pregnancy IFN-gamma responses to foetal alloantigens are altered by maternal allergy and gravidity status.
LA Breckler,
J Hale,
A Taylor,
JA Dunstan,
CA Thornton,
SL Prescott,
Cathy Thornton 
Allergy, Volume: 63, Issue: 11, Pages: 1473 - 1480
Swansea University Author:
Cathy Thornton
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1111/j.1398-9995.2008.01718.x.
Abstract
BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study...
| Published in: | Allergy |
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| ISSN: | 1398-9995 |
| Published: |
Wiley
2008
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa9994 |
| Abstract: |
BACKGROUND: During pregnancy, variations in maternal-foetal cellular interactions may influence immune programming. This study was carried out to determine if maternal responses to foetal alloantigens are altered by maternal allergic disease and/or previous pregnancies.METHODS: For this cohort study, peripheral blood was collected from allergic (n = 69) and nonallergic (n = 63) pregnant women at 20, 30, 36-week gestation and 6-week postpartum (pp). Cord blood was collected at delivery. Mixed lymphocyte reactions were used to measure maternal cytokine responses [interleukin-6 (IL-6), IL-10, IL-13 and (interferon-gamma) IFN-gamma] at each time point towards foetal mononuclear cells.RESULTS: Maternal cytokine responses during pregnancy (20, 30 and 36 weeks) were suppressed compared to the responses at 6-week pp. The ratio of maternal IFN-gamma/IL-13 and IFN-gamma/IL-10 responses were lower during pregnancy. Allergic mothers had lower IFN-gamma responses at each time-point during pregnancy with the greatest difference in responses observed at 36-week gestation. When allergic and nonallergic women were further stratified by gravidity group, IFN-gamma responses of allergic multigravid mothers were significantly lower than nonallergic multigravid mothers during pregnancy.CONCLUSIONS: During normal pregnancy, peripheral T-cell cytokine responses to foetal alloantigens may be altered by both allergic status of the mother and previous pregnancies. These factors could influence the cytokine milieu experienced by the foetus and will be further explored in the development of allergic disease during early life |
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| Keywords: |
allergy; alloimmune response; maternal–foetal interaction; pregnancy; T helper |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
11 |
| Start Page: |
1473 |
| End Page: |
1480 |