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Encapsulation of Hydrophobic Drugs Using Polymeric Micelles / TAMARA TALAKESH

Swansea University Author: TAMARA TALAKESH

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Abstract

Hydrophobic drugs, which are poorly soluble in water, present significant challenges in drug delivery due to their low bioavailability. Nanoparticles, such as micelles, have emerged as effective drug delivery vehicles that enhance the absorption efficiency of these drugs.Micelles are spherical struc...

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Published: Swansea 2026
Institution: Swansea University
Degree level: Master of Research
Degree name: MRes
Supervisor: Shirin, A.
URI: https://cronfa.swan.ac.uk/Record/cronfa72100
first_indexed 2026-06-17T12:21:33Z
last_indexed 2026-06-18T04:49:08Z
id cronfa72100
recordtype RisThesis
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spelling 2026-06-17T13:21:32.0034903 v2 72100 2026-06-17 Encapsulation of Hydrophobic Drugs Using Polymeric Micelles c39a590933e94267747173b17e8323e8 TAMARA TALAKESH TAMARA TALAKESH true false 2026-06-17 Hydrophobic drugs, which are poorly soluble in water, present significant challenges in drug delivery due to their low bioavailability. Nanoparticles, such as micelles, have emerged as effective drug delivery vehicles that enhance the absorption efficiency of these drugs.Micelles are spherical structures formed by amphiphilic molecules in aqueous environments. They have a hydrophobic core and a hydrophilic shell, making them ideal for encapsulating hydrophobic drugs. This encapsulation improves the solubility and stability of the drugs, facilitating better absorption and bioavailability. Advantages of Micelles: Enhanced Solubility, Controlled Release, and Targeted Delivery.This project aims to enhance the delivery and efficacy of hydrophobic inflammatory drugs using polymeric micelles encapsulation. The encapsulation process involves dissolving the drugs and polymers in a suitable solvent, followed by self-assembly into micelles. By studying the effects of pH and temperature on drug release, the project seeks to optimize the conditions for controlled and targeted drug delivery, potentially improving therapeutic outcomes for patients.The micelles will be tested in different pH environments to simulate conditions in various parts of the body, and the effect of temperature on drug release will be studied to understand how body temperature and potential fever conditions might influence drug delivery. E-Thesis Swansea amphiphilic polymer, biomedical engineering, Ibuprofen, encapsulation, grafted polymers, Thermosensitive, pH-responsive 23 4 2026 2026-04-23 COLLEGE NANME COLLEGE CODE Swansea University Shirin, A. Master of Research MRes 2026-06-17T13:21:32.0034903 2026-06-17T13:14:31.5087955 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering TAMARA TALAKESH 1 72100__36989__b399a495b8114236bc49edddd5a6f0cd.pdf 2026_Talakesh_T.final.72100.pdf 2026-06-17T13:20:11.4604309 Output 5459106 application/pdf E-Thesis – open access true Copyright: the author, Tamara Talakesh, 2026 true eng
title Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
spellingShingle Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
TAMARA TALAKESH
title_short Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
title_full Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
title_fullStr Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
title_full_unstemmed Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
title_sort Encapsulation of Hydrophobic Drugs Using Polymeric Micelles
author_id_str_mv c39a590933e94267747173b17e8323e8
author_id_fullname_str_mv c39a590933e94267747173b17e8323e8_***_TAMARA TALAKESH
author TAMARA TALAKESH
author2 TAMARA TALAKESH
format E-Thesis
publishDate 2026
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Hydrophobic drugs, which are poorly soluble in water, present significant challenges in drug delivery due to their low bioavailability. Nanoparticles, such as micelles, have emerged as effective drug delivery vehicles that enhance the absorption efficiency of these drugs.Micelles are spherical structures formed by amphiphilic molecules in aqueous environments. They have a hydrophobic core and a hydrophilic shell, making them ideal for encapsulating hydrophobic drugs. This encapsulation improves the solubility and stability of the drugs, facilitating better absorption and bioavailability. Advantages of Micelles: Enhanced Solubility, Controlled Release, and Targeted Delivery.This project aims to enhance the delivery and efficacy of hydrophobic inflammatory drugs using polymeric micelles encapsulation. The encapsulation process involves dissolving the drugs and polymers in a suitable solvent, followed by self-assembly into micelles. By studying the effects of pH and temperature on drug release, the project seeks to optimize the conditions for controlled and targeted drug delivery, potentially improving therapeutic outcomes for patients.The micelles will be tested in different pH environments to simulate conditions in various parts of the body, and the effect of temperature on drug release will be studied to understand how body temperature and potential fever conditions might influence drug delivery.
published_date 2026-04-23T06:03:07Z
_version_ 1868490906261258240
score 11.109323

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