E-Thesis 43 views 12 downloads
Encapsulation of Hydrophobic Drugs Using Polymeric Micelles / TAMARA TALAKESH
Swansea University Author: TAMARA TALAKESH
Abstract
Hydrophobic drugs, which are poorly soluble in water, present significant challenges in drug delivery due to their low bioavailability. Nanoparticles, such as micelles, have emerged as effective drug delivery vehicles that enhance the absorption efficiency of these drugs.Micelles are spherical struc...
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Swansea
2026
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| Institution: | Swansea University |
| Degree level: | Master of Research |
| Degree name: | MRes |
| Supervisor: | Shirin, A. |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa72100 |
| Abstract: |
Hydrophobic drugs, which are poorly soluble in water, present significant challenges in drug delivery due to their low bioavailability. Nanoparticles, such as micelles, have emerged as effective drug delivery vehicles that enhance the absorption efficiency of these drugs.Micelles are spherical structures formed by amphiphilic molecules in aqueous environments. They have a hydrophobic core and a hydrophilic shell, making them ideal for encapsulating hydrophobic drugs. This encapsulation improves the solubility and stability of the drugs, facilitating better absorption and bioavailability. Advantages of Micelles: Enhanced Solubility, Controlled Release, and Targeted Delivery.This project aims to enhance the delivery and efficacy of hydrophobic inflammatory drugs using polymeric micelles encapsulation. The encapsulation process involves dissolving the drugs and polymers in a suitable solvent, followed by self-assembly into micelles. By studying the effects of pH and temperature on drug release, the project seeks to optimize the conditions for controlled and targeted drug delivery, potentially improving therapeutic outcomes for patients.The micelles will be tested in different pH environments to simulate conditions in various parts of the body, and the effect of temperature on drug release will be studied to understand how body temperature and potential fever conditions might influence drug delivery. |
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| Keywords: |
amphiphilic polymer, biomedical engineering, Ibuprofen, encapsulation, grafted polymers, Thermosensitive, pH-responsive |
| College: |
Faculty of Science and Engineering |