Journal article 121 views
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Jürgen Brem 
,
Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt,
Karina Calvopiña,
María-Carmen Turrientes,
Madeline E. Kavanagh ,
Dmitrijs Lubriks ,
Philip Hinchliffe,
Gareth W. Langley ,
Ali F. Aboklaish,
Anders Eneroth,
Maria Backlund ,
Andrei G. Baran,
Elisabet I. Nielsen ,
Michael Speake,
Janis Kuka,
John Robinson,
Solveiga Grinberga,
Lindsay Robinson,
Michael A. McDonough ,
Anna M. Rydzik,
Thomas M. Leissing,
Juan Carlos Jimenez-Castellanos,
Matthew B. Avison,
Solange Da Silva Pinto,
Andrew D. Pannifer,
Marina Martjuga,
Emma Widlake ,
Martins Priede ,
Iva Hopkins Navratilova,
Marek Gniadkowski,
Anna Karin Belfrage ,
Peter Brandt ,
Jari Yli-Kauhaluoma ,
Eric Bacque,
Malcolm G. P. Page ,
Fredrik Björkling ,
Jon Tyrrell ,
James Spencer ,
Pauline A. Lang ,
Pawel Baranczewski ,
Rafael Cantón ,
Stuart P. McElroy,
Philip S. Jones,
Fernando Baquero,
Edgars Suna ,
Angus Morrison,
Timothy R. Walsh,
Christopher J. Schofield
,
Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt,
Karina Calvopiña,
María-Carmen Turrientes,
Madeline E. Kavanagh ,
Dmitrijs Lubriks ,
Philip Hinchliffe,
Gareth W. Langley ,
Ali F. Aboklaish,
Anders Eneroth,
Maria Backlund ,
Andrei G. Baran,
Elisabet I. Nielsen ,
Michael Speake,
Janis Kuka,
John Robinson,
Solveiga Grinberga,
Lindsay Robinson,
Michael A. McDonough ,
Anna M. Rydzik,
Thomas M. Leissing,
Juan Carlos Jimenez-Castellanos,
Matthew B. Avison,
Solange Da Silva Pinto,
Andrew D. Pannifer,
Marina Martjuga,
Emma Widlake ,
Martins Priede ,
Iva Hopkins Navratilova,
Marek Gniadkowski,
Anna Karin Belfrage ,
Peter Brandt ,
Jari Yli-Kauhaluoma ,
Eric Bacque,
Malcolm G. P. Page ,
Fredrik Björkling ,
Jon Tyrrell ,
James Spencer ,
Pauline A. Lang ,
Pawel Baranczewski ,
Rafael Cantón ,
Stuart P. McElroy,
Philip S. Jones,
Fernando Baquero,
Edgars Suna ,
Angus Morrison,
Timothy R. Walsh,
Christopher J. Schofield
Nature Chemistry, Volume: 14, Issue: 1, Pages: 15 - 24
Swansea University Author:
Jon Tyrrell
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1038/s41557-021-00831-x
Abstract
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
| Published in: | Nature Chemistry |
|---|---|
| ISSN: | 1755-4330 1755-4349 |
| Published: |
Springer Science and Business Media LLC
2022
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa70430 |
| first_indexed |
2025-09-21T22:01:41Z |
|---|---|
| last_indexed |
2025-10-17T09:30:56Z |
| id |
cronfa70430 |
| recordtype |
SURis |
| fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2025-10-16T14:08:12.3942679</datestamp><bib-version>v2</bib-version><id>70430</id><entry>2025-09-21</entry><title>Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors</title><swanseaauthors><author><sid>ad510c73555adf718387af219e235a6e</sid><ORCID>0000-0001-8565-2590</ORCID><firstname>Jon</firstname><surname>Tyrrell</surname><name>Jon Tyrrell</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-09-21</date><deptcode>MEDS</deptcode><abstract/><type>Journal Article</type><journal>Nature Chemistry</journal><volume>14</volume><journalNumber>1</journalNumber><paginationStart>15</paginationStart><paginationEnd>24</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1755-4330</issnPrint><issnElectronic>1755-4349</issnElectronic><keywords/><publishedDay>1</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-01-01</publishedDate><doi>10.1038/s41557-021-00831-x</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>The ENABLE project is financially supported by contributions from Academic and SME partners. The Oxford work was also supported by Cancer Research UK (C9047/A24759), the Medical Research Council, the Biotechnology and Biological Research Council (BB/S50676X/1) and the Ineos Oxford Institute for Antimicrobial Research (C.J.S.). This research was funded in whole, or in part, by the Wellcome Trust (grant no. 106244/Z/14/Z and no. 099141/Z/12/Z). The Bristol work was also supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) grant R01AI100560 (J.S. and P.H.) (the content is the responsibility of the authors and does not necessarily represent official views of the NIH) and the BrisSynBio Biosuite (UK Biotechnology and Biological Sciences (BBSRC) and Engineering and Physical Sciences (EPSRC) Research Councils (BB/L01386X/1) and BBSRC ALERT14 initiative (BB/M012107/1).</funders><projectreference/><lastEdited>2025-10-16T14:08:12.3942679</lastEdited><Created>2025-09-21T18:14:43.5924914</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Jürgen</firstname><surname>Brem</surname><orcid>0000-0002-0137-3226</orcid><order>1</order></author><author><firstname>Tharindi</firstname><surname>Panduwawala</surname><orcid>0000-0001-7095-1336</orcid><order>2</order></author><author><firstname>Jon Ulf</firstname><surname>Hansen</surname><order>3</order></author><author><firstname>Joanne</firstname><surname>Hewitt</surname><order>4</order></author><author><firstname>Edgars</firstname><surname>Liepins</surname><order>5</order></author><author><firstname>Pawel</firstname><surname>Donets</surname><orcid>0000-0003-4358-2429</orcid><order>6</order></author><author><firstname>Laura</firstname><surname>Espina</surname><order>7</order></author><author><firstname>Alistair J. M.</firstname><surname>Farley</surname><order>8</order></author><author><firstname>Kirill</firstname><surname>Shubin</surname><order>9</order></author><author><firstname>Gonzalo Gomez</firstname><surname>Campillos</surname><orcid>0000-0002-2405-8421</orcid><order>10</order></author><author><firstname>Paula</firstname><surname>Kiuru</surname><orcid>0000-0001-6084-684x</orcid><order>11</order></author><author><firstname>Shifali</firstname><surname>Shishodia</surname><orcid>0000-0001-8727-3877</orcid><order>12</order></author><author><firstname>Daniel</firstname><surname>Krahn</surname><order>13</order></author><author><firstname>Robert K.</firstname><surname>Leśniak</surname><order>14</order></author><author><firstname>Juliane</firstname><surname>Schmidt</surname><order>15</order></author><author><firstname>Karina</firstname><surname>Calvopiña</surname><order>16</order></author><author><firstname>María-Carmen</firstname><surname>Turrientes</surname><order>17</order></author><author><firstname>Madeline E.</firstname><surname>Kavanagh</surname><orcid>0000-0002-4735-1559</orcid><order>18</order></author><author><firstname>Dmitrijs</firstname><surname>Lubriks</surname><orcid>0000-0002-8014-4172</orcid><order>19</order></author><author><firstname>Philip</firstname><surname>Hinchliffe</surname><order>20</order></author><author><firstname>Gareth W.</firstname><surname>Langley</surname><orcid>0000-0003-0875-3712</orcid><order>21</order></author><author><firstname>Ali F.</firstname><surname>Aboklaish</surname><order>22</order></author><author><firstname>Anders</firstname><surname>Eneroth</surname><order>23</order></author><author><firstname>Maria</firstname><surname>Backlund</surname><orcid>0000-0002-6253-816x</orcid><order>24</order></author><author><firstname>Andrei G.</firstname><surname>Baran</surname><order>25</order></author><author><firstname>Elisabet I.</firstname><surname>Nielsen</surname><orcid>0000-0003-0725-214x</orcid><order>26</order></author><author><firstname>Michael</firstname><surname>Speake</surname><order>27</order></author><author><firstname>Janis</firstname><surname>Kuka</surname><order>28</order></author><author><firstname>John</firstname><surname>Robinson</surname><order>29</order></author><author><firstname>Solveiga</firstname><surname>Grinberga</surname><order>30</order></author><author><firstname>Lindsay</firstname><surname>Robinson</surname><order>31</order></author><author><firstname>Michael A.</firstname><surname>McDonough</surname><orcid>0000-0003-4664-6942</orcid><order>32</order></author><author><firstname>Anna M.</firstname><surname>Rydzik</surname><order>33</order></author><author><firstname>Thomas M.</firstname><surname>Leissing</surname><order>34</order></author><author><firstname>Juan Carlos</firstname><surname>Jimenez-Castellanos</surname><order>35</order></author><author><firstname>Matthew B.</firstname><surname>Avison</surname><order>36</order></author><author><firstname>Solange Da Silva</firstname><surname>Pinto</surname><order>37</order></author><author><firstname>Andrew D.</firstname><surname>Pannifer</surname><order>38</order></author><author><firstname>Marina</firstname><surname>Martjuga</surname><order>39</order></author><author><firstname>Emma</firstname><surname>Widlake</surname><orcid>0000-0001-6721-8643</orcid><order>40</order></author><author><firstname>Martins</firstname><surname>Priede</surname><orcid>0000-0002-9655-8345</orcid><order>41</order></author><author><firstname>Iva Hopkins</firstname><surname>Navratilova</surname><order>42</order></author><author><firstname>Marek</firstname><surname>Gniadkowski</surname><order>43</order></author><author><firstname>Anna Karin</firstname><surname>Belfrage</surname><orcid>0000-0002-6257-4064</orcid><order>44</order></author><author><firstname>Peter</firstname><surname>Brandt</surname><orcid>0000-0002-2885-2016</orcid><order>45</order></author><author><firstname>Jari</firstname><surname>Yli-Kauhaluoma</surname><orcid>0000-0003-0370-7653</orcid><order>46</order></author><author><firstname>Eric</firstname><surname>Bacque</surname><order>47</order></author><author><firstname>Malcolm G. P.</firstname><surname>Page</surname><orcid>0000-0002-0276-8174</orcid><order>48</order></author><author><firstname>Fredrik</firstname><surname>Björkling</surname><orcid>0000-0001-7018-8334</orcid><order>49</order></author><author><firstname>Jon</firstname><surname>Tyrrell</surname><orcid>0000-0001-8565-2590</orcid><order>50</order></author><author><firstname>James</firstname><surname>Spencer</surname><orcid>0000-0002-4602-0571</orcid><order>51</order></author><author><firstname>Pauline A.</firstname><surname>Lang</surname><orcid>0000-0003-3187-1469</orcid><order>52</order></author><author><firstname>Pawel</firstname><surname>Baranczewski</surname><orcid>0000-0001-5772-6791</orcid><order>53</order></author><author><firstname>Rafael</firstname><surname>Cantón</surname><orcid>0000-0003-1675-3173</orcid><order>54</order></author><author><firstname>Stuart P.</firstname><surname>McElroy</surname><order>55</order></author><author><firstname>Philip S.</firstname><surname>Jones</surname><order>56</order></author><author><firstname>Fernando</firstname><surname>Baquero</surname><order>57</order></author><author><firstname>Edgars</firstname><surname>Suna</surname><orcid>0000-0002-3078-0576</orcid><order>58</order></author><author><firstname>Angus</firstname><surname>Morrison</surname><order>59</order></author><author><firstname>Timothy R.</firstname><surname>Walsh</surname><order>60</order></author><author><firstname>Christopher J.</firstname><surname>Schofield</surname><orcid>0000-0002-0290-6565</orcid><order>61</order></author></authors><documents/><OutputDurs/></rfc1807> |
| spelling |
2025-10-16T14:08:12.3942679 v2 70430 2025-09-21 Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ad510c73555adf718387af219e235a6e 0000-0001-8565-2590 Jon Tyrrell Jon Tyrrell true false 2025-09-21 MEDS Journal Article Nature Chemistry 14 1 15 24 Springer Science and Business Media LLC 1755-4330 1755-4349 1 1 2022 2022-01-01 10.1038/s41557-021-00831-x COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University The ENABLE project is financially supported by contributions from Academic and SME partners. The Oxford work was also supported by Cancer Research UK (C9047/A24759), the Medical Research Council, the Biotechnology and Biological Research Council (BB/S50676X/1) and the Ineos Oxford Institute for Antimicrobial Research (C.J.S.). This research was funded in whole, or in part, by the Wellcome Trust (grant no. 106244/Z/14/Z and no. 099141/Z/12/Z). The Bristol work was also supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) grant R01AI100560 (J.S. and P.H.) (the content is the responsibility of the authors and does not necessarily represent official views of the NIH) and the BrisSynBio Biosuite (UK Biotechnology and Biological Sciences (BBSRC) and Engineering and Physical Sciences (EPSRC) Research Councils (BB/L01386X/1) and BBSRC ALERT14 initiative (BB/M012107/1). 2025-10-16T14:08:12.3942679 2025-09-21T18:14:43.5924914 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Jürgen Brem 0000-0002-0137-3226 1 Tharindi Panduwawala 0000-0001-7095-1336 2 Jon Ulf Hansen 3 Joanne Hewitt 4 Edgars Liepins 5 Pawel Donets 0000-0003-4358-2429 6 Laura Espina 7 Alistair J. M. Farley 8 Kirill Shubin 9 Gonzalo Gomez Campillos 0000-0002-2405-8421 10 Paula Kiuru 0000-0001-6084-684x 11 Shifali Shishodia 0000-0001-8727-3877 12 Daniel Krahn 13 Robert K. Leśniak 14 Juliane Schmidt 15 Karina Calvopiña 16 María-Carmen Turrientes 17 Madeline E. Kavanagh 0000-0002-4735-1559 18 Dmitrijs Lubriks 0000-0002-8014-4172 19 Philip Hinchliffe 20 Gareth W. Langley 0000-0003-0875-3712 21 Ali F. Aboklaish 22 Anders Eneroth 23 Maria Backlund 0000-0002-6253-816x 24 Andrei G. Baran 25 Elisabet I. Nielsen 0000-0003-0725-214x 26 Michael Speake 27 Janis Kuka 28 John Robinson 29 Solveiga Grinberga 30 Lindsay Robinson 31 Michael A. McDonough 0000-0003-4664-6942 32 Anna M. Rydzik 33 Thomas M. Leissing 34 Juan Carlos Jimenez-Castellanos 35 Matthew B. Avison 36 Solange Da Silva Pinto 37 Andrew D. Pannifer 38 Marina Martjuga 39 Emma Widlake 0000-0001-6721-8643 40 Martins Priede 0000-0002-9655-8345 41 Iva Hopkins Navratilova 42 Marek Gniadkowski 43 Anna Karin Belfrage 0000-0002-6257-4064 44 Peter Brandt 0000-0002-2885-2016 45 Jari Yli-Kauhaluoma 0000-0003-0370-7653 46 Eric Bacque 47 Malcolm G. P. Page 0000-0002-0276-8174 48 Fredrik Björkling 0000-0001-7018-8334 49 Jon Tyrrell 0000-0001-8565-2590 50 James Spencer 0000-0002-4602-0571 51 Pauline A. Lang 0000-0003-3187-1469 52 Pawel Baranczewski 0000-0001-5772-6791 53 Rafael Cantón 0000-0003-1675-3173 54 Stuart P. McElroy 55 Philip S. Jones 56 Fernando Baquero 57 Edgars Suna 0000-0002-3078-0576 58 Angus Morrison 59 Timothy R. Walsh 60 Christopher J. Schofield 0000-0002-0290-6565 61 |
| title |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| spellingShingle |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors Jon Tyrrell |
| title_short |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| title_full |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| title_fullStr |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| title_full_unstemmed |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| title_sort |
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors |
| author_id_str_mv |
ad510c73555adf718387af219e235a6e |
| author_id_fullname_str_mv |
ad510c73555adf718387af219e235a6e_***_Jon Tyrrell |
| author |
Jon Tyrrell |
| author2 |
Jürgen Brem Tharindi Panduwawala Jon Ulf Hansen Joanne Hewitt Edgars Liepins Pawel Donets Laura Espina Alistair J. M. Farley Kirill Shubin Gonzalo Gomez Campillos Paula Kiuru Shifali Shishodia Daniel Krahn Robert K. Leśniak Juliane Schmidt Karina Calvopiña María-Carmen Turrientes Madeline E. Kavanagh Dmitrijs Lubriks Philip Hinchliffe Gareth W. Langley Ali F. Aboklaish Anders Eneroth Maria Backlund Andrei G. Baran Elisabet I. Nielsen Michael Speake Janis Kuka John Robinson Solveiga Grinberga Lindsay Robinson Michael A. McDonough Anna M. Rydzik Thomas M. Leissing Juan Carlos Jimenez-Castellanos Matthew B. Avison Solange Da Silva Pinto Andrew D. Pannifer Marina Martjuga Emma Widlake Martins Priede Iva Hopkins Navratilova Marek Gniadkowski Anna Karin Belfrage Peter Brandt Jari Yli-Kauhaluoma Eric Bacque Malcolm G. P. Page Fredrik Björkling Jon Tyrrell James Spencer Pauline A. Lang Pawel Baranczewski Rafael Cantón Stuart P. McElroy Philip S. Jones Fernando Baquero Edgars Suna Angus Morrison Timothy R. Walsh Christopher J. Schofield |
| format |
Journal article |
| container_title |
Nature Chemistry |
| container_volume |
14 |
| container_issue |
1 |
| container_start_page |
15 |
| publishDate |
2022 |
| institution |
Swansea University |
| issn |
1755-4330 1755-4349 |
| doi_str_mv |
10.1038/s41557-021-00831-x |
| publisher |
Springer Science and Business Media LLC |
| college_str |
Faculty of Medicine, Health and Life Sciences |
| hierarchytype |
|
| hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
| hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
| hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
| department_str |
Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science |
| document_store_str |
0 |
| active_str |
0 |
| published_date |
2022-01-01T05:30:52Z |
| _version_ |
1851098034073501696 |
| score |
11.089386 |