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Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors

Sumati Bhatia Orcid Logo, Malte Hilsch, Jose Luis Cuellar‐Camacho Orcid Logo, Kai Ludwig Orcid Logo, Chuanxiong Nie Orcid Logo, Badri Parshad Orcid Logo, Matthias Wallert, Stephan Block Orcid Logo, Daniel Lauster Orcid Logo, Christoph Böttcher, Andreas Herrmann Orcid Logo, Rainer Haag Orcid Logo

Angewandte Chemie, Volume: 132, Issue: 30, Pages: 12517 - 12522

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/ange.202006145

Abstract

Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza...

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Published in: Angewandte Chemie
ISSN: 0044-8249 1521-3757
Published: Wiley 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa64864
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spelling v2 64864 2023-11-01 Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 CHEM Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells. Journal Article Angewandte Chemie 132 30 12517 12522 Wiley 0044-8249 1521-3757 Flexibility, infection inhibition, influenza A virus, polyglycerols, sialylated nanogels 13 7 2020 2020-07-13 10.1002/ange.202006145 http://dx.doi.org/10.1002/ange.202006145 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University Deutsche Forschungsgemeinschaft (Grant Number: SFB 765/3-2019). 2024-01-02T13:16:11.1700065 2023-11-01T10:38:55.2381714 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Sumati Bhatia 0000-0002-5123-4937 1 Malte Hilsch 2 Jose Luis Cuellar‐Camacho 0000-0002-9218-2678 3 Kai Ludwig 0000-0001-6808-8107 4 Chuanxiong Nie 0000-0001-7963-1187 5 Badri Parshad 0000-0001-6496-8844 6 Matthias Wallert 7 Stephan Block 0000-0002-2947-0837 8 Daniel Lauster 0000-0003-2009-633x 9 Christoph Böttcher 10 Andreas Herrmann 0000-0002-6716-2026 11 Rainer Haag 0000-0003-3840-162x 12 64864__29332__d800eda3e6654fff8b615436afabe4eb.pdf 64864.VOR.pdf 2024-01-02T10:37:34.9523473 Output 3214584 application/pdf Version of Record true © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
spellingShingle Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Sumati Bhatia
title_short Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
title_full Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
title_fullStr Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
title_full_unstemmed Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
title_sort Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
author_id_str_mv a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author Sumati Bhatia
author2 Sumati Bhatia
Malte Hilsch
Jose Luis Cuellar‐Camacho
Kai Ludwig
Chuanxiong Nie
Badri Parshad
Matthias Wallert
Stephan Block
Daniel Lauster
Christoph Böttcher
Andreas Herrmann
Rainer Haag
format Journal article
container_title Angewandte Chemie
container_volume 132
container_issue 30
container_start_page 12517
publishDate 2020
institution Swansea University
issn 0044-8249
1521-3757
doi_str_mv 10.1002/ange.202006145
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1002/ange.202006145
document_store_str 1
active_str 0
description Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells.
published_date 2020-07-13T13:16:13Z
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score 11.013731

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