Journal article 351 views
Wrapping and Blocking of Influenza A Viruses by Sialylated 2D Nanoplatforms
Sumati Bhatia 
,
Ievgen S. Donskyi,
Stephan Block,
Chuanxiong Nie,
Angelique Burdinski,
Daniel Lauster,
Jörg Radnik,
Andreas Herrmann,
Rainer Haag,
Kai Ludwig,
Mohsen Adeli
,
Ievgen S. Donskyi,
Stephan Block,
Chuanxiong Nie,
Angelique Burdinski,
Daniel Lauster,
Jörg Radnik,
Andreas Herrmann,
Rainer Haag,
Kai Ludwig,
Mohsen Adeli
Advanced Materials Interfaces, Volume: 8, Issue: 12
Swansea University Author:
Sumati Bhatia
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DOI (Published version): 10.1002/admi.202100285
Abstract
Inhibition of respiratory viruses is one of the most urgent topics as underlined by different pandemics in the last two decades. This impels the development of new materials for binding and incapacitation of the viruses. In this work, we have demonstrated that an optimal deployment of influenza A vi...
| Published in: | Advanced Materials Interfaces |
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| ISSN: | 2196-7350 2196-7350 |
| Published: |
Wiley
2021
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64861 |
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| Abstract: |
Inhibition of respiratory viruses is one of the most urgent topics as underlined by different pandemics in the last two decades. This impels the development of new materials for binding and incapacitation of the viruses. In this work, we have demonstrated that an optimal deployment of influenza A virus (IAV) targeting ligand sialic acid (SA) on a flexible 2D platform enables its binding and wrapping around IAV particles. A series of 2D sialylated platforms consisting graphene and polyglycerol are prepared with different degrees of SA functionalization around 10%, 30%, and 90% named as G-PG-SAL, G-PG-SAM, and G-PG-SAH, respectively. The cryo-electron tomography (Cryo-ET) analysis has proved wrapping of IAV particles by G-PG-SAM. A confocal-based colocalization assay established for these materials has offered the comparison of binding potential of sialylated and non-sialylated nanoplatforms for IAV. With this method, we have estimated the binding potential of the G-PG-SAM and G-PG-SAH sheets for IAV particles around 50 and 20 times higher than the control sheets, respectively, whereas the low functionalized G-PG-SAL have not shown any significant colocalization value. Moreover, optimized G-PG-SAM exhibits high potency to block IAV from binding with the MDCK cells. |
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| Keywords: |
2D materials, graphene, influenza A virus, sialic acid, wrapping |
| College: |
Faculty of Science and Engineering |
| Funders: |
Deutsche Forschungsgemeinschaft DFG (Grant Number: SFB 765). |
| Issue: |
12 |