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Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
,
Malte Hilsch,
Jose Luis Cuellar‐Camacho ,
Kai Ludwig ,
Chuanxiong Nie ,
Badri Parshad ,
Matthias Wallert,
Stephan Block ,
Daniel Lauster ,
Christoph Böttcher,
Andreas Herrmann ,
Rainer Haag
Angewandte Chemie, Volume: 132, Issue: 30, Pages: 12517 - 12522
Swansea University Author:
Sumati Bhatia
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© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0).
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DOI (Published version): 10.1002/ange.202006145
Abstract
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza...
| Published in: | Angewandte Chemie |
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| ISSN: | 0044-8249 1521-3757 |
| Published: |
Wiley
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64864 |
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| Abstract: |
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells. |
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| Keywords: |
Flexibility, infection inhibition, influenza A virus, polyglycerols, sialylated nanogels |
| College: |
Faculty of Science and Engineering |
| Funders: |
Deutsche Forschungsgemeinschaft (Grant Number: SFB 765/3-2019). |
| Issue: |
30 |
| Start Page: |
12517 |
| End Page: |
12522 |