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Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications / PRANAV PREMDAS

Swansea University Author: PRANAV PREMDAS

Abstract

This thesis focuses on the development of green synthetic methods and strategies for the production of cationic lipophilic gold nanoparticles (AuNPs) and hydrophobic organic compound such as hydroxylpropyltripheylphosphonium bromide. For the green synthesis of the latter, a novel approach for method...

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Published: Swansea, Wales, UK 2023
Institution: Swansea University
Degree level: Master of Research
Degree name: MSc by Research
Supervisor: Ju-Nam, Yon. and Ojeda Ledo, Jesus.
URI: https://cronfa.swan.ac.uk/Record/cronfa63697
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first_indexed 2023-06-23T14:40:01Z
last_indexed 2023-06-23T14:40:01Z
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spelling v2 63697 2023-06-23 Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications 3ee8e8182edeba71df415ddf4b2dd14b PRANAV PREMDAS PRANAV PREMDAS true false 2023-06-23 This thesis focuses on the development of green synthetic methods and strategies for the production of cationic lipophilic gold nanoparticles (AuNPs) and hydrophobic organic compound such as hydroxylpropyltripheylphosphonium bromide. For the green synthesis of the latter, a novel approach for method development was successfully employed, which consisted of the use of Aspen Plus simulation software to model the reaction between triphenylphosphine and bromopropanol in 100% water, prior planning experimental work in the laboratory.Operating parameters generated from the simulation work (100% water, temperature 850C, reaction time 5 hours, atmospheric pressure) were replicated in the laboratory, and hydroxylpropyltripheylphosphonium bromide crystals were obtained. The infrared spectrum of this compound indicated the presence of the most characteristic functional groups from the chemical structure (-OH, P-C, C=C and C-H). The initial Aspen simulation work helped to reduce excessive use of reactants and reagents, and chemical wastage in the laboratory.Following the theme of this thesis, green chemistry principles were employed to improve the synthesis of cationic lipophilic AuNPs. Two green methods were developed for the functionalisation of AuNPs both using different ratios of dimethylformamide: water (1:2 and 1:5) and reaction temperatures of 80 and 1000C, following different orders in which the reactants were mixed. TEM analyses showed that the mixing order of the reactants, temperature and concentration of reducing agent were the main factors affecting the particle sizes in the gold colloidal samples (3.13 – 8.01 nm). Cationic lipophilic AuNPs prepared following a greener method showed good stability over a period of 6 months. E-Thesis Swansea, Wales, UK Gold nanoparticles, ligand, Aspen Plus, Transmission electron microscopy, X-ray photoelectron spectroscopy 9 6 2023 2023-06-09 COLLEGE NANME COLLEGE CODE Swansea University Ju-Nam, Yon. and Ojeda Ledo, Jesus. Master of Research MSc by Research 2023-06-23T15:44:21.8479211 2023-06-23T15:36:32.8300562 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering PRANAV PREMDAS 1 Under embargo Under embargo 2023-06-23T15:41:06.3555213 Output 4666774 application/pdf E-Thesis – open access true 2024-06-12T00:00:00.0000000 Copyright: The Author, Pranav Pazhamukku Premdas, 2023. Distributed under the terms of a Creative Commons Attribution Non Commercial 4.0 License (CC BY-NC 4.0). true eng https://creativecommons.org/licenses/by-nc/4.0/
title Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
spellingShingle Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
PRANAV PREMDAS
title_short Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
title_full Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
title_fullStr Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
title_full_unstemmed Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
title_sort Green synthesis of lipophilic capping agents and functionalised gold nanoparticles for potential biomedical applications
author_id_str_mv 3ee8e8182edeba71df415ddf4b2dd14b
author_id_fullname_str_mv 3ee8e8182edeba71df415ddf4b2dd14b_***_PRANAV PREMDAS
author PRANAV PREMDAS
author2 PRANAV PREMDAS
format E-Thesis
publishDate 2023
institution Swansea University
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering
document_store_str 0
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description This thesis focuses on the development of green synthetic methods and strategies for the production of cationic lipophilic gold nanoparticles (AuNPs) and hydrophobic organic compound such as hydroxylpropyltripheylphosphonium bromide. For the green synthesis of the latter, a novel approach for method development was successfully employed, which consisted of the use of Aspen Plus simulation software to model the reaction between triphenylphosphine and bromopropanol in 100% water, prior planning experimental work in the laboratory.Operating parameters generated from the simulation work (100% water, temperature 850C, reaction time 5 hours, atmospheric pressure) were replicated in the laboratory, and hydroxylpropyltripheylphosphonium bromide crystals were obtained. The infrared spectrum of this compound indicated the presence of the most characteristic functional groups from the chemical structure (-OH, P-C, C=C and C-H). The initial Aspen simulation work helped to reduce excessive use of reactants and reagents, and chemical wastage in the laboratory.Following the theme of this thesis, green chemistry principles were employed to improve the synthesis of cationic lipophilic AuNPs. Two green methods were developed for the functionalisation of AuNPs both using different ratios of dimethylformamide: water (1:2 and 1:5) and reaction temperatures of 80 and 1000C, following different orders in which the reactants were mixed. TEM analyses showed that the mixing order of the reactants, temperature and concentration of reducing agent were the main factors affecting the particle sizes in the gold colloidal samples (3.13 – 8.01 nm). Cationic lipophilic AuNPs prepared following a greener method showed good stability over a period of 6 months.
published_date 2023-06-09T15:44:17Z
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score 11.013037

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