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Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins

Vinod Khatri, Badri Parshad, Ashok K. Prasad, Sumati Bhatia Orcid Logo

European Journal of Organic Chemistry, Volume: 26, Issue: 9

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/ejoc.202201360

Abstract

In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydr...

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Published in: European Journal of Organic Chemistry
ISSN: 1434-193X 1099-0690
Published: Wiley 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa64853
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Abstract: In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review.
Keywords: Carbohydrates, Drug delivery, Glycotripod, Hemagglutinin, Lectin binder
College: Faculty of Science and Engineering
Funders: We acknowledge the funding from the German Research Foundation (DFG) – project number 458564133 to support this work. Open Access funding enabled and organized by Projekt DEAL.
Issue: 9

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