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Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study

Jananie Suntharesan, Navoda Atapattu Orcid Logo, Eresha Jasinghe, Sagarika Ekanayake, Delpachitra Acharige Gajabahu Haren de Silva, Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo, Lakdasa Premawardhana Orcid Logo

Archives of Disease in Childhood, Volume: 108, Issue: 1, Pages: 47 - 52

Swansea University Authors: Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo

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Abstract

Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin,...

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Published in: Archives of Disease in Childhood
ISSN: 0003-9888 1468-2044
Published: BMJ 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61944
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Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10&#x2013;14&#x2009;years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180&#x2009;min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, &#x2206;Cmax, p&lt;0.05; area under the curve, &#x2206;AUC0&#x2013;3, p&lt;0.01) and meal M3 (maximal concentration, Cmax, p&lt;0.01; &#x2206;Cmax, p&lt;0.001, and &#x2206;AUC0&#x2013;3p&lt;0.01). M2 also produced lower insulin values compared with M1 (p&lt;0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p&lt;0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. 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spelling 2023-01-20T14:49:35.5211615 v2 61944 2022-11-18 Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false 01491e1cd582746a654fad9addf0de16 0000-0002-7206-6530 Steve Luzio Steve Luzio true false 2022-11-18 BMS Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007. Journal Article Archives of Disease in Childhood 108 1 47 52 BMJ 0003-9888 1468-2044 15 12 2022 2022-12-15 10.1136/archdischild-2022-324203 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Not Required This work was supported by Stella de Silva Research grant of Sri Lanka College of Paediatricians. 2023-01-20T14:49:35.5211615 2022-11-18T09:39:33.0227225 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Jananie Suntharesan 1 Navoda Atapattu 0000-0002-3398-2536 2 Eresha Jasinghe 3 Sagarika Ekanayake 4 Delpachitra Acharige Gajabahu Haren de Silva 5 Gareth Dunseath 0000-0001-6022-862X 6 Steve Luzio 0000-0002-7206-6530 7 Lakdasa Premawardhana 0000-0003-0931-3700 8 61944__25871__8e71575411644e91abd46dc799ee3bd0.pdf 61944.pdf 2022-11-22T15:54:38.2429757 Output 411676 application/pdf Version of Record true © Author(s) (or their employer(s)) 2022. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license true eng http://creativecommons.org/licenses/by-nc/4.0/ 140
title Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
spellingShingle Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
Gareth Dunseath
Steve Luzio
title_short Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
title_full Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
title_fullStr Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
title_full_unstemmed Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
title_sort Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study
author_id_str_mv fccbba9edcaee08a839a3c5cff8cbe19
01491e1cd582746a654fad9addf0de16
author_id_fullname_str_mv fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath
01491e1cd582746a654fad9addf0de16_***_Steve Luzio
author Gareth Dunseath
Steve Luzio
author2 Jananie Suntharesan
Navoda Atapattu
Eresha Jasinghe
Sagarika Ekanayake
Delpachitra Acharige Gajabahu Haren de Silva
Gareth Dunseath
Steve Luzio
Lakdasa Premawardhana
format Journal article
container_title Archives of Disease in Childhood
container_volume 108
container_issue 1
container_start_page 47
publishDate 2022
institution Swansea University
issn 0003-9888
1468-2044
doi_str_mv 10.1136/archdischild-2022-324203
publisher BMJ
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007.
published_date 2022-12-15T04:16:04Z
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