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Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study

Jananie Suntharesan, Navoda Atapattu Orcid Logo, Eresha Jasinghe, Sagarika Ekanayake, Delpachitra Acharige Gajabahu Haren de Silva, Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo, Lakdasa Premawardhana Orcid Logo

Archives of Disease in Childhood, Pages: archdischild - 2022

Swansea University Authors: Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo

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Abstract

Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin,...

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Published in: Archives of Disease in Childhood
ISSN: 0003-9888 1468-2044
Published: BMJ 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa61944
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Abstract: Introduction Resistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.Objectives We aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.Methods This was a single blind, non-randomised, crossover study of 20 obese children aged 10–14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.Results Meal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆Cmax, p<0.05; area under the curve, ∆AUC0–3, p<0.01) and meal M3 (maximal concentration, Cmax, p<0.01; ∆Cmax, p<0.001, and ∆AUC0–3p<0.01). M2 also produced lower insulin values compared with M1 (p<0.05). Postprandial ghrelin was significantly higher after M1 compared with M3 (p<0.05). PYY, GLP1 and median satiety scores were not significantly different between the three meals.Conclusion This study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals.Trial registration number SLCTR/2020/007.
College: Swansea University Medical School
Funders: This work was supported by Stella de Silva Research grant of Sri Lanka College of Paediatricians.
Start Page: archdischild
End Page: 2022