Core Steps to the Azaphilone Family of Fungal Natural Products

Williams, Katherine; Greco, Claudio; Bailey, Andrew M.; Willis, Christine L.

doi:10.1002/cbic.202100240

Journal article 1095 views 212 downloads

Core Steps to the Azaphilone Family of Fungal Natural Products

Katherine Williams

, Claudio Greco

, Andrew M. Bailey

, Christine L. Willis

ChemBioChem, Volume: 22, Issue: 21, Pages: 3027 - 3036

Swansea University Author: Claudio Greco

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DOI (Published version): 10.1002/cbic.202100240

Abstract

Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaph...

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Published in:	ChemBioChem
ISSN:	1439-4227 1439-7633
Published:	Wiley 2021
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61515

first_indexed	2022-10-20T12:31:47Z
last_indexed	2023-01-13T19:22:18Z
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spelling	2022-10-20T13:34:31.3689882 v2 61515 2022-10-10 Core Steps to the Azaphilone Family of Fungal Natural Products cacac6459bd7cf4a241f63661006036f 0000-0003-3067-0999 Claudio Greco Claudio Greco true false 2022-10-10 BGPS Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways. Journal Article ChemBioChem 22 21 3027 3036 Wiley 1439-4227 1439-7633 azaphilone; biosynthesis; genome mining; natural products; pathway elucidation 3 11 2021 2021-11-03 10.1002/cbic.202100240 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University MRC. Grant Number: MR/N029909/1; BBSRC. Grant Number: BB/V005723/1 2022-10-20T13:34:31.3689882 2022-10-10T17:23:40.0861619 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Katherine Williams 0000-0002-1988-8818 1 Claudio Greco 0000-0003-3067-0999 2 Andrew M. Bailey 0000-0002-7594-3703 3 Christine L. Willis 0000-0002-3919-3642 4 61515__25523__3a239c6ffeb54d2dac40f3514cc692de.pdf 61515_VoR.pdf 2022-10-20T13:33:15.8655605 Output 16213704 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title	Core Steps to the Azaphilone Family of Fungal Natural Products
spellingShingle	Core Steps to the Azaphilone Family of Fungal Natural Products Claudio Greco
title_short	Core Steps to the Azaphilone Family of Fungal Natural Products
title_full	Core Steps to the Azaphilone Family of Fungal Natural Products
title_fullStr	Core Steps to the Azaphilone Family of Fungal Natural Products
title_full_unstemmed	Core Steps to the Azaphilone Family of Fungal Natural Products
title_sort	Core Steps to the Azaphilone Family of Fungal Natural Products
author_id_str_mv	cacac6459bd7cf4a241f63661006036f
author_id_fullname_str_mv	cacac6459bd7cf4a241f63661006036f_***_Claudio Greco
author	Claudio Greco
author2	Katherine Williams Claudio Greco Andrew M. Bailey Christine L. Willis
format	Journal article
container_title	ChemBioChem
container_volume	22
container_issue	21
container_start_page	3027
publishDate	2021
institution	Swansea University
issn	1439-4227 1439-7633
doi_str_mv	10.1002/cbic.202100240
publisher	Wiley
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description	Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.
published_date	2021-11-03T05:07:34Z
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Core Steps to the Azaphilone Family of Fungal Natural Products

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