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Core Steps to the Azaphilone Family of Fungal Natural Products
,
Claudio Greco ,
Andrew M. Bailey ,
Christine L. Willis
ChemBioChem, Volume: 22, Issue: 21, Pages: 3027 - 3036
Swansea University Author:
Claudio Greco
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DOI (Published version): 10.1002/cbic.202100240
Abstract
Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaph...
| Published in: | ChemBioChem |
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| ISSN: | 1439-4227 1439-7633 |
| Published: |
Wiley
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61515 |
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| Abstract: |
Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways. |
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| Keywords: |
azaphilone; biosynthesis; genome mining; natural products; pathway elucidation |
| College: |
Faculty of Science and Engineering |
| Funders: |
MRC. Grant Number: MR/N029909/1; BBSRC. Grant Number: BB/V005723/1 |
| Issue: |
21 |
| Start Page: |
3027 |
| End Page: |
3036 |