Journal article 631 views 49 downloads
Variations in COVID-19 vaccination uptake among people in receipt of psychotropic drugs: cross-sectional analysis of a national population-based prospective cohort
,
Dermot O'Reilly ,
Rhiannon Owen ,
Ashley Akbari ,
Emily Lowthian,
Stuart Bedston,
Fatemeh Torabi ,
Jillian Beggs,
Antony Chuter,
Simon de Lusignan ,
Richard Hobbs ,
Chris Robertson,
Srinivasa Vittal Katikireddi ,
Aziz Sheikh ,
Declan T. Bradley
The British Journal of Psychiatry, Volume: 221, Issue: 1, Pages: 417 - 424
Swansea University Authors:
Rhiannon Owen , Ashley Akbari , Emily Lowthian, Stuart Bedston, Fatemeh Torabi
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© The Author(s), 2022. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence
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DOI (Published version): 10.1192/bjp.2022.36
Abstract
BackgroundCoronavirus disease 2019 (COVID-19) has disproportionately affected people with mental health conditions.AimsWe investigated the association between receiving psychotropic drugs, as an indicator of mental health conditions, and COVID-19 vaccine uptake.MethodWe conducted a cross-sectional a...
| Published in: | The British Journal of Psychiatry |
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| ISSN: | 0007-1250 1472-1465 |
| Published: |
Royal College of Psychiatrists
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59519 |
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| Abstract: |
BackgroundCoronavirus disease 2019 (COVID-19) has disproportionately affected people with mental health conditions.AimsWe investigated the association between receiving psychotropic drugs, as an indicator of mental health conditions, and COVID-19 vaccine uptake.MethodWe conducted a cross-sectional analysis of a prospective cohort of the Northern Ireland adult population using national linked primary care registration, vaccination, secondary care and pharmacy dispensing data. Univariable and multivariable logistic regression analyses investigated the association between anxiolytic, antidepressant, antipsychotic, and hypnotic use and COVID-19 vaccination status, accounting for age, gender, deprivation and comorbidities. Receiving any COVID-19 vaccine was the primary outcome.ResultsThere were 1 433 814 individuals, of whom 1 166 917 received a COVID-19 vaccination. Psychotropic medications were dispensed to 267 049 people. In univariable analysis, people who received any psychotropic medication had greater odds of receiving COVID-19 vaccination: odds ratio (OR) = 1.42 (95% CI 1.41–1.44). However, after adjustment, psychotropic medication use was associated with reduced odds of vaccination (ORadj = 0.90, 95% CI 0.89–0.91). People who received anxiolytics (ORadj = 0.63, 95% CI 0.61–0.65), antipsychotics (ORadj = 0.75, 95% CI 0.73–0.78) and hypnotics (ORadj = 0.90, 95% CI 0.87–0.93) had reduced odds of being vaccinated. Antidepressant use was not associated with vaccination (ORadj = 1.02, 95% CI 1.00–1.03).ConclusionsWe found significantly lower odds of vaccination in people who were receiving treatment with anxiolytic and antipsychotic medications. There is an urgent need for evidence-based, tailored vaccine support for people with mental health conditions. |
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| Keywords: |
Covid-19; vaccines; mental health; equity; psychotropic medicines |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
UK Research and Innovation (Medical Research Council); Research and Innovation Industrial Strategy Challenge Fund; Health Data Research UK |
| Issue: |
1 |
| Start Page: |
417 |
| End Page: |
424 |