Journal article 528 views 130 downloads
Cholesterol metabolism: from lipidomics to immunology
,
Yuqin Wang
Journal of Lipid Research, Volume: 63, Issue: 2, Start page: 100165
Swansea University Authors:
William Griffiths , Yuqin Wang
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DOI (Published version): 10.1016/j.jlr.2021.100165
Abstract
Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo, other than as intermediates in bile acid biosyn...
| Published in: | Journal of Lipid Research |
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| ISSN: | 0022-2275 |
| Published: |
Elsevier BV
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59064 |
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| Abstract: |
Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo, other than as intermediates in bile acid biosynthesis, has long been debated. However, in first quarter of this century, a role for side-chain oxysterols and their C-7 oxidized metabolites has been convincingly established in the immune system. 25-Hydroxycholesterol has been shown to be synthesized by macrophages in response to the activation of Toll-like receptors and to offer protection against microbial pathogens, while 7α,25-dihydroxycholesterol has been shown to act as a chemoattractant to lymphocytes expressing the G protein-coupled receptor EBI2 and to be important in coordinating the action of B, T, and dendritic cells in secondary lymphoid tissue. There is a growing body of evidence that not only these two oxysterols but also many of their isomers are of importance to the proper function of the immune system. Here, we review recent findings related to the roles of oxysterols in immunology. |
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| Keywords: |
oxysterol; hydroxycholesterol; accessible cholesterol; macrophage; B cell; T cell; dendritic cell; virus; bacterial infection; membrane fusion |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by the UKRI Biotechnology and Biological Sciences Research Council (BBSRC, grant numbers BB/I001735/1 and BB/N015932/1 to WJG, BB/L001942/1 to YW). |
| Issue: |
2 |
| Start Page: |
100165 |