Journal article 1627 views 314 downloads
Defective cholesterol metabolism in amyotrophic lateral sclerosis
,
Peter J. Crick,
Jan-Åke Gustafsson,
Margaret Warner,
Gustavo Roman,
Kevin Talbot,
Elizabeth Gray,
William Griffiths ,
Martin R. Turner,
Yuqin Wang
Journal of Lipid Research, Start page: jlr.P071639
Swansea University Authors:
Eylan Yutuc , William Griffiths , Yuqin Wang
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DOI (Published version): 10.1194/jlr.P071639
Abstract
As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. More than 40 different...
| Published in: | Journal of Lipid Research |
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| ISSN: | 0022-2275 1539-7262 |
| Published: |
2017
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa30987 |
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| Abstract: |
As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. More than 40 different sterols were quantified in serum and cerebrospinal fluid (CSF) from ALS patients and healthy controls. In CSF the concentration of cholesterol was found to be elevated in ALS samples. When CSF metabolite levels were normalised to cholesterol, the cholesterol metabolite 3beta,7alpha-dihydroxycholest-5-en-26-oic acid, along with its precursor 3beta-hydroxycholest-5-en-26-oic acid and product 7alpha-hydroxy-3-oxocholest-4-en-26-oic acid were reduced in concentration, whereas metabolites known to be imported from the circulation into the CNS were not found to differ in concentration between groups. Analysis of serum revealed that (25R)26-hydroxycholesterol, the immediate precursor of 3beta-hydroxycholest-5-en-26-oic acid was reduced in concentration in ALS patients compared to controls. We conclude that the acidic branch of bile acid biosynthesis, known to operative in-part in brain, is defective in ALS leading to a failure of the CNS to remove excess cholesterol which may be toxic to neuronal cells, compounded by a reduction in neuroprotective 3beta,7alpha-dihydroxycholest-5-en-26-oic acid. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
jlr.P071639 |