Journal article 1281 views 142 downloads
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Ruochen Zang,
James Brett Case,
Eylan Yutuc 
,
Xiucui Ma,
Sheng Shen,
Maria Florencia Gomez Castro,
Zhuoming Liu,
Qiru Zeng,
Haiyan Zhao,
Juhee Son,
Paul W. Rothlauf,
Alex J. B. Kreutzberger,
Gaopeng Hou,
Hu Zhang,
Sayantan Bose,
Xin Wang,
Michael D. Vahey,
Kartik Mani,
William Griffiths ,
Tom Kirchhausen,
Daved H. Fremont,
Haitao Guo,
Abhinav Diwan,
Yuqin Wang ,
Michael S. Diamond,
Sean P. J. Whelan,
Siyuan Ding
,
Xiucui Ma,
Sheng Shen,
Maria Florencia Gomez Castro,
Zhuoming Liu,
Qiru Zeng,
Haiyan Zhao,
Juhee Son,
Paul W. Rothlauf,
Alex J. B. Kreutzberger,
Gaopeng Hou,
Hu Zhang,
Sayantan Bose,
Xin Wang,
Michael D. Vahey,
Kartik Mani,
William Griffiths ,
Tom Kirchhausen,
Daved H. Fremont,
Haitao Guo,
Abhinav Diwan,
Yuqin Wang ,
Michael S. Diamond,
Sean P. J. Whelan,
Siyuan Ding
Proceedings of the National Academy of Sciences, Volume: 117, Issue: 50, Pages: 32105 - 32113
Swansea University Authors:
Eylan Yutuc , William Griffiths , Yuqin Wang
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DOI (Published version): 10.1073/pnas.2012197117
Abstract
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people and caused tens of thousands of deaths. There are no Food and...
| Published in: | Proceedings of the National Academy of Sciences |
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| ISSN: | 0027-8424 1091-6490 |
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Proceedings of the National Academy of Sciences
2020
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<?xml version="1.0"?><rfc1807><datestamp>2020-12-21T13:27:56.2040669</datestamp><bib-version>v2</bib-version><id>55583</id><entry>2020-11-03</entry><title>Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion</title><swanseaauthors><author><sid>99332f073ce913a9b7d8b6441b17516d</sid><ORCID>0000-0001-9971-1950</ORCID><firstname>Eylan</firstname><surname>Yutuc</surname><name>Eylan Yutuc</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>3316b1d1b524be1831790933eed1c26e</sid><ORCID>0000-0002-4129-6616</ORCID><firstname>William</firstname><surname>Griffiths</surname><name>William Griffiths</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>c92729b58622f9fdf6a0e7d8f4ce5081</sid><ORCID>0000-0002-3063-3066</ORCID><firstname>Yuqin</firstname><surname>Wang</surname><name>Yuqin Wang</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-11-03</date><deptcode>BMS</deptcode><abstract>The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people and caused tens of thousands of deaths. There are no Food and Drug Administration-approved antivirals or vaccines yet available and clinical treatments are limited to supportive therapies that help alleviate the symptoms. Thus, there is an urgent need to identify effective antivirals as countermeasures before safe and effective vaccines are developed, tested, and then produced on a large scale. Our approach is to harness the germline-encoded interferon antiviral response to inhibit SARS-CoV-2 replication thereby limiting its pathogenicity</abstract><type>Journal Article</type><journal>Proceedings of the National Academy of Sciences</journal><volume>117</volume><journalNumber>50</journalNumber><paginationStart>32105</paginationStart><paginationEnd>32113</paginationEnd><publisher>Proceedings of the National Academy of Sciences</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0027-8424</issnPrint><issnElectronic>1091-6490</issnElectronic><keywords>SARS-CoV-2; interferon; virus entry; COVID-19; innate immunity</keywords><publishedDay>15</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-12-15</publishedDate><doi>10.1073/pnas.2012197117</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-12-21T13:27:56.2040669</lastEdited><Created>2020-11-03T09:35:52.5261441</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Ruochen</firstname><surname>Zang</surname><order>1</order></author><author><firstname>James Brett</firstname><surname>Case</surname><order>2</order></author><author><firstname>Eylan</firstname><surname>Yutuc</surname><orcid>0000-0001-9971-1950</orcid><order>3</order></author><author><firstname>Xiucui</firstname><surname>Ma</surname><order>4</order></author><author><firstname>Sheng</firstname><surname>Shen</surname><order>5</order></author><author><firstname>Maria Florencia Gomez</firstname><surname>Castro</surname><order>6</order></author><author><firstname>Zhuoming</firstname><surname>Liu</surname><order>7</order></author><author><firstname>Qiru</firstname><surname>Zeng</surname><order>8</order></author><author><firstname>Haiyan</firstname><surname>Zhao</surname><order>9</order></author><author><firstname>Juhee</firstname><surname>Son</surname><order>10</order></author><author><firstname>Paul W.</firstname><surname>Rothlauf</surname><order>11</order></author><author><firstname>Alex J. 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2020-12-21T13:27:56.2040669 v2 55583 2020-11-03 Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion 99332f073ce913a9b7d8b6441b17516d 0000-0001-9971-1950 Eylan Yutuc Eylan Yutuc true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2020-11-03 BMS The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people and caused tens of thousands of deaths. There are no Food and Drug Administration-approved antivirals or vaccines yet available and clinical treatments are limited to supportive therapies that help alleviate the symptoms. Thus, there is an urgent need to identify effective antivirals as countermeasures before safe and effective vaccines are developed, tested, and then produced on a large scale. Our approach is to harness the germline-encoded interferon antiviral response to inhibit SARS-CoV-2 replication thereby limiting its pathogenicity Journal Article Proceedings of the National Academy of Sciences 117 50 32105 32113 Proceedings of the National Academy of Sciences 0027-8424 1091-6490 SARS-CoV-2; interferon; virus entry; COVID-19; innate immunity 15 12 2020 2020-12-15 10.1073/pnas.2012197117 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2020-12-21T13:27:56.2040669 2020-11-03T09:35:52.5261441 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Ruochen Zang 1 James Brett Case 2 Eylan Yutuc 0000-0001-9971-1950 3 Xiucui Ma 4 Sheng Shen 5 Maria Florencia Gomez Castro 6 Zhuoming Liu 7 Qiru Zeng 8 Haiyan Zhao 9 Juhee Son 10 Paul W. Rothlauf 11 Alex J. B. Kreutzberger 12 Gaopeng Hou 13 Hu Zhang 14 Sayantan Bose 15 Xin Wang 16 Michael D. Vahey 17 Kartik Mani 18 William Griffiths 0000-0002-4129-6616 19 Tom Kirchhausen 20 Daved H. Fremont 21 Haitao Guo 22 Abhinav Diwan 23 Yuqin Wang 0000-0002-3063-3066 24 Michael S. Diamond 25 Sean P. J. Whelan 26 Siyuan Ding 27 55583__18748__27bea0901ce147f187d37525e9014901.pdf 2012197117.full.pdf 2020-11-26T08:45:38.2353401 Output 1477724 application/pdf Version of Record true This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). true eng http://creativecommons.org/licenses/by/4.0/ |
| title |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| spellingShingle |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion Eylan Yutuc William Griffiths Yuqin Wang |
| title_short |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| title_full |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| title_fullStr |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| title_full_unstemmed |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| title_sort |
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |
| author_id_str_mv |
99332f073ce913a9b7d8b6441b17516d 3316b1d1b524be1831790933eed1c26e c92729b58622f9fdf6a0e7d8f4ce5081 |
| author_id_fullname_str_mv |
99332f073ce913a9b7d8b6441b17516d_***_Eylan Yutuc 3316b1d1b524be1831790933eed1c26e_***_William Griffiths c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang |
| author |
Eylan Yutuc William Griffiths Yuqin Wang |
| author2 |
Ruochen Zang James Brett Case Eylan Yutuc Xiucui Ma Sheng Shen Maria Florencia Gomez Castro Zhuoming Liu Qiru Zeng Haiyan Zhao Juhee Son Paul W. Rothlauf Alex J. B. Kreutzberger Gaopeng Hou Hu Zhang Sayantan Bose Xin Wang Michael D. Vahey Kartik Mani William Griffiths Tom Kirchhausen Daved H. Fremont Haitao Guo Abhinav Diwan Yuqin Wang Michael S. Diamond Sean P. J. Whelan Siyuan Ding |
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Proceedings of the National Academy of Sciences |
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117 |
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50 |
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32105 |
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2020 |
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10.1073/pnas.2012197117 |
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Proceedings of the National Academy of Sciences |
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Faculty of Medicine, Health and Life Sciences |
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The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people and caused tens of thousands of deaths. There are no Food and Drug Administration-approved antivirals or vaccines yet available and clinical treatments are limited to supportive therapies that help alleviate the symptoms. Thus, there is an urgent need to identify effective antivirals as countermeasures before safe and effective vaccines are developed, tested, and then produced on a large scale. Our approach is to harness the germline-encoded interferon antiviral response to inhibit SARS-CoV-2 replication thereby limiting its pathogenicity |
| published_date |
2020-12-15T04:09:54Z |
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11.037319 |