Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Ortega, Santiago Schiaffino; Chayah, Mariem; Salvador, Maria Kimatrai; Lopez-Cara, Luisa Carlota; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Ronca, Roberto; Bortolozzi, Roberta; Mariotto, Elena; Mattiuzzo, Elena; Viola, Giampietro

doi:10.1021/acs.jmedchem.8b01391

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Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Pier Giovanni Baraldi, Santiago Schiaffino Ortega, Mariem Chayah, Maria Kimatrai Salvador, Luisa Carlota Lopez-Cara, Andrea Brancale, Salvatore Ferla

, Ernest Hamel, Roberto Ronca, Roberta Bortolozzi, Elena Mariotto, Elena Mattiuzzo, Giampietro Viola

Journal of Medicinal Chemistry, Volume: 62, Issue: 3, Pages: 1274 - 1290

Swansea University Author: Salvatore Ferla

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DOI (Published version): 10.1021/acs.jmedchem.8b01391

Published in:	Journal of Medicinal Chemistry
ISSN:	0022-2623 1520-4804
Published:	American Chemical Society (ACS) 2019
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa55238
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first_indexed	2020-10-20T06:19:59Z
last_indexed	2020-11-06T04:17:01Z
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spelling	2020-11-05T16:53:11.8463669 v2 55238 2020-09-20 Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors d4c62248f510e3b221916989a7bbe6a6 0000-0002-5918-9237 Salvatore Ferla Salvatore Ferla true false 2020-09-20 PHAR Journal Article Journal of Medicinal Chemistry 62 3 1274 1290 American Chemical Society (ACS) 0022-2623 1520-4804 14 2 2019 2019-02-14 10.1021/acs.jmedchem.8b01391 http://orca.cf.ac.uk/120345/ COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University 2020-11-05T16:53:11.8463669 2020-09-20T14:39:54.4864804 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Romeo Romagnoli 1 Filippo Prencipe 2 Paola Oliva 3 Stefania Baraldi 4 Pier Giovanni Baraldi 5 Santiago Schiaffino Ortega 6 Mariem Chayah 7 Maria Kimatrai Salvador 8 Luisa Carlota Lopez-Cara 9 Andrea Brancale 10 Salvatore Ferla 0000-0002-5918-9237 11 Ernest Hamel 12 Roberto Ronca 13 Roberta Bortolozzi 14 Elena Mariotto 15 Elena Mattiuzzo 16 Giampietro Viola 17
title	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
spellingShingle	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors Salvatore Ferla
title_short	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
title_full	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
title_fullStr	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
title_full_unstemmed	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
title_sort	Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
author_id_str_mv	d4c62248f510e3b221916989a7bbe6a6
author_id_fullname_str_mv	d4c62248f510e3b221916989a7bbe6a6_***_Salvatore Ferla
author	Salvatore Ferla
author2	Romeo Romagnoli Filippo Prencipe Paola Oliva Stefania Baraldi Pier Giovanni Baraldi Santiago Schiaffino Ortega Mariem Chayah Maria Kimatrai Salvador Luisa Carlota Lopez-Cara Andrea Brancale Salvatore Ferla Ernest Hamel Roberto Ronca Roberta Bortolozzi Elena Mariotto Elena Mattiuzzo Giampietro Viola
format	Journal article
container_title	Journal of Medicinal Chemistry
container_volume	62
container_issue	3
container_start_page	1274
publishDate	2019
institution	Swansea University
issn	0022-2623 1520-4804
doi_str_mv	10.1021/acs.jmedchem.8b01391
publisher	American Chemical Society (ACS)
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url	http://orca.cf.ac.uk/120345/
document_store_str	0
active_str	0
published_date	2019-02-14T04:09:18Z
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score	11.037056

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

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