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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Maria Encarnacion Camacho, Chiara Padroni, Andrea Brancale, Salvatore Ferla Orcid Logo, Ernest Hamel, Roberto Ronca, Elisabetta Grillo, Roberta Bortolozzi, Fatlum Rruga, Elena Mariotto, Giampietro Viola

European Journal of Medicinal Chemistry, Volume: 181, Start page: 111577

Swansea University Author: Salvatore Ferla Orcid Logo

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Published in: European Journal of Medicinal Chemistry
ISSN: 0223-5234
Published: Elsevier BV 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa55235
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Keywords: Microtubules; Structure-activity relationship; 1H-pyrazole; Antiproliferative activity; Tubulin
College: Faculty of Medicine, Health and Life Sciences
Start Page: 111577