Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Camacho, Maria Encarnacion; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Ronca, Roberto; Grillo, Elisabetta; Bortolozzi, Roberta; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro

doi:10.1016/j.ejmech.2019.111577

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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Maria Encarnacion Camacho, Chiara Padroni, Andrea Brancale, Salvatore Ferla

, Ernest Hamel, Roberto Ronca, Elisabetta Grillo, Roberta Bortolozzi, Fatlum Rruga, Elena Mariotto, Giampietro Viola

European Journal of Medicinal Chemistry, Volume: 181, Start page: 111577

Swansea University Author: Salvatore Ferla

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DOI (Published version): 10.1016/j.ejmech.2019.111577

Published in:	European Journal of Medicinal Chemistry
ISSN:	0223-5234
Published:	Elsevier BV 2019
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa55235

first_indexed	2020-10-20T06:18:55Z
last_indexed	2020-11-07T04:14:19Z
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spelling	2020-11-06T11:44:27.8921742 v2 55235 2020-09-20 Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors d4c62248f510e3b221916989a7bbe6a6 0000-0002-5918-9237 Salvatore Ferla Salvatore Ferla true false 2020-09-20 MEDS Journal Article European Journal of Medicinal Chemistry 181 111577 Elsevier BV 0223-5234 Microtubules; Structure-activity relationship; 1H-pyrazole; Antiproliferative activity; Tubulin 1 11 2019 2019-11-01 10.1016/j.ejmech.2019.111577 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2020-11-06T11:44:27.8921742 2020-09-20T14:30:42.9213672 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Romeo Romagnoli 1 Paola Oliva 2 Maria Kimatrai Salvador 3 Maria Encarnacion Camacho 4 Chiara Padroni 5 Andrea Brancale 6 Salvatore Ferla 0000-0002-5918-9237 7 Ernest Hamel 8 Roberto Ronca 9 Elisabetta Grillo 10 Roberta Bortolozzi 11 Fatlum Rruga 12 Elena Mariotto 13 Giampietro Viola 14
title	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
spellingShingle	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors Salvatore Ferla
title_short	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
title_full	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
title_fullStr	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
title_full_unstemmed	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
title_sort	Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
author_id_str_mv	d4c62248f510e3b221916989a7bbe6a6
author_id_fullname_str_mv	d4c62248f510e3b221916989a7bbe6a6_***_Salvatore Ferla
author	Salvatore Ferla
author2	Romeo Romagnoli Paola Oliva Maria Kimatrai Salvador Maria Encarnacion Camacho Chiara Padroni Andrea Brancale Salvatore Ferla Ernest Hamel Roberto Ronca Elisabetta Grillo Roberta Bortolozzi Fatlum Rruga Elena Mariotto Giampietro Viola
format	Journal article
container_title	European Journal of Medicinal Chemistry
container_volume	181
container_start_page	111577
publishDate	2019
institution	Swansea University
issn	0223-5234
doi_str_mv	10.1016/j.ejmech.2019.111577
publisher	Elsevier BV
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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published_date	2019-11-01T04:50:39Z
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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

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