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Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites

William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

Prostaglandins & Other Lipid Mediators, Volume: 147, Start page: 106381

Swansea University Authors: William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

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DOI (Published version): 10.1016/j.prostaglandins.2019.106381

Abstract

There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol...

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Published in: Prostaglandins & Other Lipid Mediators
ISSN: 1098-8823
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa52696
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first_indexed 2019-11-10T04:14:16Z
last_indexed 2020-10-30T04:06:21Z
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spelling 2020-10-29T13:18:59.4724866 v2 52696 2019-11-10 Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2019-11-10 BMS There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease. Journal Article Prostaglandins & Other Lipid Mediators 147 106381 Elsevier BV 1098-8823 Hydroxycholesterol, Dihydroxycholesterol, Epoxycholesterol, G protein-coupled receptor, Epstein Barr virus induced gene 2, Smoothened, Hedgehog signaling, Nuclear receptor, Liver X receptor 1 4 2020 2020-04-01 10.1016/j.prostaglandins.2019.106381 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University UKRI, BB/N015932/1 2020-10-29T13:18:59.4724866 2019-11-10T01:50:13.5205824 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 0000-0002-3063-3066 2 52696__16045__59400e66d6e04bbbaf3068a362152f76.pdf 52696.pdf 2019-12-05T11:22:31.8146028 Output 1753865 application/pdf Version of Record true Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY) Licence true eng https://creativecommons.org/licenses/by/4.0/ 4 true true
title Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
spellingShingle Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
William Griffiths
Yuqin Wang
title_short Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
title_full Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
title_fullStr Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
title_full_unstemmed Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
title_sort Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
c92729b58622f9fdf6a0e7d8f4ce5081
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
author William Griffiths
Yuqin Wang
author2 William Griffiths
Yuqin Wang
format Journal article
container_title Prostaglandins & Other Lipid Mediators
container_volume 147
container_start_page 106381
publishDate 2020
institution Swansea University
issn 1098-8823
doi_str_mv 10.1016/j.prostaglandins.2019.106381
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease.
published_date 2020-04-01T04:05:13Z
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score 11.037603

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