Journal article 652 views 177 downloads
Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
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Yuqin Wang
Prostaglandins & Other Lipid Mediators, Volume: 147, Start page: 106381
Swansea University Authors:
William Griffiths , Yuqin Wang
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DOI (Published version): 10.1016/j.prostaglandins.2019.106381
Abstract
There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol...
| Published in: | Prostaglandins & Other Lipid Mediators |
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| ISSN: | 1098-8823 |
| Published: |
Elsevier BV
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa52696 |
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| Abstract: |
There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease. |
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| Keywords: |
Hydroxycholesterol, Dihydroxycholesterol, Epoxycholesterol, G protein-coupled receptor, Epstein Barr virus induced gene 2, Smoothened, Hedgehog signaling, Nuclear receptor, Liver X receptor |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
UKRI, BB/N015932/1 |
| Start Page: |
106381 |