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Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

William Griffiths Orcid Logo, Jonas Abdel-Khalik, Eylan Yutuc Orcid Logo, Gustavo Roman, Margaret Warner, Jan-Åke Gustafsson, Yuqin Wang

Free Radical Biology and Medicine, Volume: 134, Pages: 42 - 52

Swansea University Authors: William Griffiths Orcid Logo, Eylan Yutuc Orcid Logo

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DOI (Published version): 10.1016/j.freeradbiomed.2018.12.020

Abstract

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodi...

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Published in: Free Radical Biology and Medicine
ISSN: 08915849
Published: 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa48010
first_indexed 2018-12-21T14:00:24Z
last_indexed 2019-09-24T20:09:20Z
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spelling 2019-09-24T16:01:01.8783098 v2 48010 2018-12-21 Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 99332f073ce913a9b7d8b6441b17516d 0000-0001-9971-1950 Eylan Yutuc Eylan Yutuc true false 2018-12-21 MEDS Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer’s disease patient-group. This was the only sterol found to be changed amongst the different groups. Journal Article Free Radical Biology and Medicine 134 42 52 08915849 Sterol; Cholesterol; Oxysterol; Cholestenoic acid; Bile acid; Brain; Neurodegenerative disease; Mass spectrometry, Cytochrome P450. 30 4 2019 2019-04-30 10.1016/j.freeradbiomed.2018.12.020 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University RCUK, BB/N015932/1 2019-09-24T16:01:01.8783098 2018-12-21T08:34:34.3207937 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Jonas Abdel-Khalik 2 Eylan Yutuc 0000-0001-9971-1950 3 Gustavo Roman 4 Margaret Warner 5 Jan-Åke Gustafsson 6 Yuqin Wang 7 0048010-07012019163530.pdf 48010.pdf 2019-01-07T16:35:30.9430000 Output 1603967 application/pdf Version of Record true 2019-01-06T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
spellingShingle Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
William Griffiths
Eylan Yutuc
title_short Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_full Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_fullStr Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_full_unstemmed Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_sort Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
99332f073ce913a9b7d8b6441b17516d
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
99332f073ce913a9b7d8b6441b17516d_***_Eylan Yutuc
author William Griffiths
Eylan Yutuc
author2 William Griffiths
Jonas Abdel-Khalik
Eylan Yutuc
Gustavo Roman
Margaret Warner
Jan-Åke Gustafsson
Yuqin Wang
format Journal article
container_title Free Radical Biology and Medicine
container_volume 134
container_start_page 42
publishDate 2019
institution Swansea University
issn 08915849
doi_str_mv 10.1016/j.freeradbiomed.2018.12.020
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer’s disease patient-group. This was the only sterol found to be changed amongst the different groups.
published_date 2019-04-30T19:37:48Z
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