Journal article 1099 views 169 downloads
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
,
Jonas Abdel-Khalik,
Eylan Yutuc ,
Gustavo Roman,
Margaret Warner,
Jan-Åke Gustafsson,
Yuqin Wang
Free Radical Biology and Medicine, Volume: 134, Pages: 42 - 52
Swansea University Authors:
William Griffiths , Eylan Yutuc
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DOI (Published version): 10.1016/j.freeradbiomed.2018.12.020
Abstract
Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodi...
| Published in: | Free Radical Biology and Medicine |
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| ISSN: | 08915849 |
| Published: |
2019
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa48010 |
| Abstract: |
Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer’s disease patient-group. This was the only sterol found to be changed amongst the different groups. |
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| Keywords: |
Sterol; Cholesterol; Oxysterol; Cholestenoic acid; Bile acid; Brain; Neurodegenerative disease; Mass spectrometry, Cytochrome P450. |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
42 |
| End Page: |
52 |