On the future of “omics”: lipidomics

Griffiths, William; Ogundare, Michael; Williams, Christopher M.; Wang, Yuqin

doi:10.1007/s10545-010-9274-4

Journal article 908 views

On the future of “omics”: lipidomics

William Griffiths

, Michael Ogundare, Christopher M. Williams, Yuqin Wang

Journal of Inherited Metabolic Disease, Volume: 34, Issue: 3, Pages: 583 - 592

Swansea University Authors: William Griffiths , Yuqin Wang

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DOI (Published version): 10.1007/s10545-010-9274-4

Abstract

Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds...

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Published in:	Journal of Inherited Metabolic Disease
ISSN:	0141-8955 1573-2665
Published:	2011
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa10761
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first_indexed	2013-07-23T12:04:13Z
last_indexed	2018-08-17T13:54:43Z
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recordtype	SURis
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spelling	2018-08-17T10:37:49.0783207 v2 10761 2012-05-21 On the future of “omics”: lipidomics 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2012-05-21 BMS Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds soluble in aqueous solutions or those soluble in organic solvents. A complete molecular and quantitative investigation of the latter when isolated from tissue, fluid or cells constitutes lipidomics. Like proteomics, lipidomics is a subject which is both technology driven and technology driving, with the primary technologies being mass spectrometry, with or without on-line chromatography and computer-assisted data analysis. In this paper we will examine the underlying fundamentals of different lipidomic experimental approaches including the “shotgun” and “top-down” global approaches, and the more targeted liquid chromatography – or gas chromatography – mass spectrometry approaches. Application of these approaches to the identification of in-born errors of metabolism will be discussed. Journal Article Journal of Inherited Metabolic Disease 34 3 583 592 0141-8955 1573-2665 30 6 2011 2011-06-30 10.1007/s10545-010-9274-4 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2018-08-17T10:37:49.0783207 2012-05-21T15:45:17.7837425 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Michael Ogundare 2 Christopher M. Williams 3 Yuqin Wang 0000-0002-3063-3066 4
title	On the future of “omics”: lipidomics
spellingShingle	On the future of “omics”: lipidomics William Griffiths Yuqin Wang
title_short	On the future of “omics”: lipidomics
title_full	On the future of “omics”: lipidomics
title_fullStr	On the future of “omics”: lipidomics
title_full_unstemmed	On the future of “omics”: lipidomics
title_sort	On the future of “omics”: lipidomics
author_id_str_mv	3316b1d1b524be1831790933eed1c26e c92729b58622f9fdf6a0e7d8f4ce5081
author_id_fullname_str_mv	3316b1d1b524be1831790933eed1c26e_*_William Griffiths c92729b58622f9fdf6a0e7d8f4ce5081_*_Yuqin Wang
author	William Griffiths Yuqin Wang
author2	William Griffiths Michael Ogundare Christopher M. Williams Yuqin Wang
format	Journal article
container_title	Journal of Inherited Metabolic Disease
container_volume	34
container_issue	3
container_start_page	583
publishDate	2011
institution	Swansea University
issn	0141-8955 1573-2665
doi_str_mv	10.1007/s10545-010-9274-4
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds soluble in aqueous solutions or those soluble in organic solvents. A complete molecular and quantitative investigation of the latter when isolated from tissue, fluid or cells constitutes lipidomics. Like proteomics, lipidomics is a subject which is both technology driven and technology driving, with the primary technologies being mass spectrometry, with or without on-line chromatography and computer-assisted data analysis. In this paper we will examine the underlying fundamentals of different lipidomic experimental approaches including the “shotgun” and “top-down” global approaches, and the more targeted liquid chromatography – or gas chromatography – mass spectrometry approaches. Application of these approaches to the identification of in-born errors of metabolism will be discussed.
published_date	2011-06-30T03:12:14Z
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score	11.013148

On the future of “omics”: lipidomics

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