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Presymptomatic differences in Toll-like receptor function in infants who have allergy.

SL Prescott, P Noakes, al BW Chow et, L Breckler, CA Thornton, EM Hollams, M Ali, AH van den Biggelaar, MK Tulic, Cathy Thornton Orcid Logo

Journal of Allergy and Clinical Immunology, Volume: 122, Issue: 2, Pages: 391 - 399

Swansea University Author: Cathy Thornton Orcid Logo

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DOI (Published version): 10.1016/j.jaci.2008.04.042

Abstract

BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy d...

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Published in: Journal of Allergy and Clinical Immunology
ISSN: 00916749
Published: Elsevier 2008
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URI: https://cronfa.swan.ac.uk/Record/cronfa9991
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spelling 2013-11-08T11:15:03.4890358 v2 9991 2012-03-21 Presymptomatic differences in Toll-like receptor function in infants who have allergy. c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2012-03-21 BMS BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development.METHODS: Cord blood mononuclear cells (n = 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-gamma (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age.RESULTS: Maternal allergy (n = 59) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n = 32). Notably, consistent with previous reports, newborns who had disease had lower T(H)1 IFN-gamma response to mitogens (PHA).CONCLUSION: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both. Journal Article Journal of Allergy and Clinical Immunology 122 2 391 399 Elsevier 00916749 allergy; early life; immunity; toll like receptors 31 12 2008 2008-12-31 10.1016/j.jaci.2008.04.042 http://www.sciencedirect.com/science/article/pii/S0091674908007884 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2013-11-08T11:15:03.4890358 2012-03-21T16:17:15.0000000 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine SL Prescott 1 P Noakes 2 al BW Chow et 3 L Breckler 4 CA Thornton 5 EM Hollams 6 M Ali 7 AH van den Biggelaar 8 MK Tulic 9 Cathy Thornton 0000-0002-5153-573X 10
title Presymptomatic differences in Toll-like receptor function in infants who have allergy.
spellingShingle Presymptomatic differences in Toll-like receptor function in infants who have allergy.
Cathy Thornton
title_short Presymptomatic differences in Toll-like receptor function in infants who have allergy.
title_full Presymptomatic differences in Toll-like receptor function in infants who have allergy.
title_fullStr Presymptomatic differences in Toll-like receptor function in infants who have allergy.
title_full_unstemmed Presymptomatic differences in Toll-like receptor function in infants who have allergy.
title_sort Presymptomatic differences in Toll-like receptor function in infants who have allergy.
author_id_str_mv c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
author Cathy Thornton
author2 SL Prescott
P Noakes
al BW Chow et
L Breckler
CA Thornton
EM Hollams
M Ali
AH van den Biggelaar
MK Tulic
Cathy Thornton
format Journal article
container_title Journal of Allergy and Clinical Immunology
container_volume 122
container_issue 2
container_start_page 391
publishDate 2008
institution Swansea University
issn 00916749
doi_str_mv 10.1016/j.jaci.2008.04.042
publisher Elsevier
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.sciencedirect.com/science/article/pii/S0091674908007884
document_store_str 0
active_str 0
description BACKGROUND: Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs).OBJECTIVE: This study explored the association between neonatal TLR microbial recognition/function, allergy risk (maternal allergy), and prospective allergy development.METHODS: Cord blood mononuclear cells (n = 111) were cultured either alone or with optimal concentrations of TLR ligands: lipoteichoic acid (TLR2), polyinosinicpolycytidylic acid (TLR3), LPS with IFN-gamma (TLR4), flagellin (TLR5), imiquimod R837 (TLR7), or CpG (TLR9). Cytokine responses were assessed in relation to allergy risk (maternal allergy) and allergy outcomes (sensitization, food allergy, and atopic dermatitis) at 12 months of age.RESULTS: Maternal allergy (n = 59) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease (n = 32). Notably, consistent with previous reports, newborns who had disease had lower T(H)1 IFN-gamma response to mitogens (PHA).CONCLUSION: Allergic disease was associated with increased (rather than decreased) perinatal TLR responses. Further studies are needed to determine how these responses track in the postnatal period and whether this relative hyperresponsiveness is a product of intrauterine influences, including maternal atopy, functional genetic polymorphisms, or both.
published_date 2008-12-31T03:11:28Z
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