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Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations

Rajesh Sreedharan Nair, Nashiru Billa, Ajay Babu Pazhayattil, Sarath Chandran C., Mohammed Tahir Ansari, Kai Bin Liew, Andrew Morris Orcid Logo

Natural Product Research, Pages: 1 - 17

Swansea University Author: Andrew Morris Orcid Logo

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DOI (Published version): 10.1080/14786419.2026.2669679

Abstract

Curcumin, one of the prominent curcuminoids present in turmeric, possesses significant value in the pharmaceutical industry owing to its diverse array of pharmacological activities, including antimicrobial, anti-inflammatory, antiviral, antioxidant, and anti-cancer properties. Traditionally used for...

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Published in: Natural Product Research
ISSN: 1478-6419 1478-6427
Published: Informa UK Limited 2026
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa71864
first_indexed 2026-05-07T13:12:19Z
last_indexed 2026-05-19T11:18:27Z
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spelling 2026-05-18T15:44:48.1971009 v2 71864 2026-05-07 Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations 3d7a7f540a5143114fcaf67e4c68d151 0000-0002-6315-7553 Andrew Morris Andrew Morris true false 2026-05-07 MEDS Curcumin, one of the prominent curcuminoids present in turmeric, possesses significant value in the pharmaceutical industry owing to its diverse array of pharmacological activities, including antimicrobial, anti-inflammatory, antiviral, antioxidant, and anti-cancer properties. Traditionally used for mild skin conditions, curcumin has recently shown significant potential in treating dermatological cancers and promoting wound healing. However, it has poor dermal absorption due to low solubility and limited skin permeation. Applying appropriate formulation strategies appears to be gaining traction as a means to harness its full therapeutic value. In this regard, nano formulations of curcumin have proven useful in managing certain skin conditions. This review focuses on the topical applications of various curcumin nanoformulations, with a particular emphasis on wound healing and anti-skin cancer effects. We analyze the reported in vitro and in vivo studies of commonly used curcumin nanoformulations in this area and comprehensively discuss various formulation approaches to achieve optimum therapeutic efficacy. Journal Article Natural Product Research 0 1 17 Informa UK Limited 1478-6419 1478-6427 10 5 2026 2026-05-10 10.1080/14786419.2026.2669679 Review Article COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2026-05-18T15:44:48.1971009 2026-05-07T14:07:32.8859630 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Rajesh Sreedharan Nair 1 Nashiru Billa 2 Ajay Babu Pazhayattil 3 Sarath Chandran C. 4 Mohammed Tahir Ansari 5 Kai Bin Liew 6 Andrew Morris 0000-0002-6315-7553 7 71864__36783__909c8b3dfffa4a459eff3f00c3a12915.pdf 71864.VOR.pdf 2026-05-18T15:41:34.8453939 Output 1565052 application/pdf Version of Record true © 2026 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
spellingShingle Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
Andrew Morris
title_short Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
title_full Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
title_fullStr Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
title_full_unstemmed Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
title_sort Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations
author_id_str_mv 3d7a7f540a5143114fcaf67e4c68d151
author_id_fullname_str_mv 3d7a7f540a5143114fcaf67e4c68d151_***_Andrew Morris
author Andrew Morris
author2 Rajesh Sreedharan Nair
Nashiru Billa
Ajay Babu Pazhayattil
Sarath Chandran C.
Mohammed Tahir Ansari
Kai Bin Liew
Andrew Morris
format Journal article
container_title Natural Product Research
container_volume 0
container_start_page 1
publishDate 2026
institution Swansea University
issn 1478-6419
1478-6427
doi_str_mv 10.1080/14786419.2026.2669679
publisher Informa UK Limited
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str 1
active_str 0
description Curcumin, one of the prominent curcuminoids present in turmeric, possesses significant value in the pharmaceutical industry owing to its diverse array of pharmacological activities, including antimicrobial, anti-inflammatory, antiviral, antioxidant, and anti-cancer properties. Traditionally used for mild skin conditions, curcumin has recently shown significant potential in treating dermatological cancers and promoting wound healing. However, it has poor dermal absorption due to low solubility and limited skin permeation. Applying appropriate formulation strategies appears to be gaining traction as a means to harness its full therapeutic value. In this regard, nano formulations of curcumin have proven useful in managing certain skin conditions. This review focuses on the topical applications of various curcumin nanoformulations, with a particular emphasis on wound healing and anti-skin cancer effects. We analyze the reported in vitro and in vivo studies of commonly used curcumin nanoformulations in this area and comprehensively discuss various formulation approaches to achieve optimum therapeutic efficacy.
published_date 2026-05-10T17:20:34Z
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