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Enhancing the therapeutic efficacy of curcumin in topical applications through nanoformulations

Rajesh Sreedharan Nair, Nashiru Billa, Ajay Babu Pazhayattil, Sarath Chandran C., Mohammed Tahir Ansari, Kai Bin Liew, Andrew Morris Orcid Logo

Natural Product Research, Pages: 1 - 17

Swansea University Author: Andrew Morris Orcid Logo

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Abstract

Curcumin, one of the prominent curcuminoids present in turmeric, possesses significant value in the pharmaceutical industry owing to its diverse array of pharmacological activities, including antimicrobial, anti-inflammatory, antiviral, antioxidant, and anti-cancer properties. Traditionally used for...

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Published in: Natural Product Research
ISSN: 1478-6419 1478-6427
Published: Informa UK Limited 2026
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa71864
Abstract: Curcumin, one of the prominent curcuminoids present in turmeric, possesses significant value in the pharmaceutical industry owing to its diverse array of pharmacological activities, including antimicrobial, anti-inflammatory, antiviral, antioxidant, and anti-cancer properties. Traditionally used for mild skin conditions, curcumin has recently shown significant potential in treating dermatological cancers and promoting wound healing. However, it has poor dermal absorption due to low solubility and limited skin permeation. Applying appropriate formulation strategies appears to be gaining traction as a means to harness its full therapeutic value. In this regard, nano formulations of curcumin have proven useful in managing certain skin conditions. This review focuses on the topical applications of various curcumin nanoformulations, with a particular emphasis on wound healing and anti-skin cancer effects. We analyze the reported in vitro and in vivo studies of commonly used curcumin nanoformulations in this area and comprehensively discuss various formulation approaches to achieve optimum therapeutic efficacy.
Item Description: Review Article
College: Faculty of Medicine, Health and Life Sciences
Funders: Swansea University
Start Page: 1
End Page: 17