No Cover Image

Book chapter 96 views 29 downloads

Multiscale modeling of biomechanical properties of red blood cells

Adesola Ademiloye Orcid Logo, Jorge Molina, MOHAMMAD ABUGHABUSH, Yang Zhang, Ping Xiang

Recent Advances in Hemodynamics and Blood Mimetics, Pages: 145 - 164

Swansea University Authors: Adesola Ademiloye Orcid Logo, MOHAMMAD ABUGHABUSH

DOI (Published version): 10.1016/b978-0-443-24066-9.00008-8

Abstract

In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by...

Full description

Published in: Recent Advances in Hemodynamics and Blood Mimetics
ISBN: 9780443240669
Published: Elsevier 2026
Online Access: https://doi.org/10.1016/b978-0-443-24066-9.00008-8
URI: https://cronfa.swan.ac.uk/Record/cronfa71198
first_indexed 2026-01-06T10:45:39Z
last_indexed 2026-01-07T05:26:49Z
id cronfa71198
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2026-01-06T10:51:42.3764663</datestamp><bib-version>v2</bib-version><id>71198</id><entry>2026-01-06</entry><title>Multiscale modeling of biomechanical properties of red blood cells</title><swanseaauthors><author><sid>e37960ed89a7e3eaeba2201762626594</sid><ORCID>0000-0002-9741-6488</ORCID><firstname>Adesola</firstname><surname>Ademiloye</surname><name>Adesola Ademiloye</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>a667fc43fa020d8902e69ae71e5ad473</sid><firstname>MOHAMMAD</firstname><surname>ABUGHABUSH</surname><name>MOHAMMAD ABUGHABUSH</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2026-01-06</date><deptcode>EAAS</deptcode><abstract>In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by different blood-related diseases such as malaria, sickle cell anemia and diabetes mellitus, they experience impaired deformability. Several experimental and numerical techniques have been proposed to elucidate the primary reasons for the observed impaired deformability and increased stiffening of RBC membrane. Multiscale modelling as a candidate numerical technique for this purpose is of particular interest since it incorporates more intrinsic details such as cellular architecture, microscale defects and substructural changes into its constitutive formulation, often resulting to improved accuracy and better computational efficiency. This chapter discusses some of the recent advances in multiscale modelling of the biomechanical properties of red blood cells. These advances include, among many others, efforts to accurately predict the biomechanical properties of healthy and diseased RBCs using a multiscale meshfree modelling framework. It also provides insights into how microstructural and temperature changes influence their deformability, pathogenesis, and pathophysiology. Furthermore, some perspectives on the multiscale modelling of biomechanical behaviors of RBCs are presented.</abstract><type>Book chapter</type><journal>Recent Advances in Hemodynamics and Blood Mimetics</journal><volume/><journalNumber/><paginationStart>145</paginationStart><paginationEnd>164</paginationEnd><publisher>Elsevier</publisher><placeOfPublication/><isbnPrint>9780443240669</isbnPrint><isbnElectronic/><issnPrint/><issnElectronic/><keywords>Computational Physiology; Multiscale modelling; Meshfree method; Biomechanical properties; Red blood cells; Malaria</keywords><publishedDay>1</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2026</publishedYear><publishedDate>2026-01-01</publishedDate><doi>10.1016/b978-0-443-24066-9.00008-8</doi><url>https://doi.org/10.1016/b978-0-443-24066-9.00008-8</url><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2026-01-06T10:51:42.3764663</lastEdited><Created>2026-01-06T10:27:03.7023703</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Adesola</firstname><surname>Ademiloye</surname><orcid>0000-0002-9741-6488</orcid><order>1</order></author><author><firstname>Jorge</firstname><surname>Molina</surname><order>2</order></author><author><firstname>MOHAMMAD</firstname><surname>ABUGHABUSH</surname><order>3</order></author><author><firstname>Yang</firstname><surname>Zhang</surname><order>4</order></author><author><firstname>Ping</firstname><surname>Xiang</surname><order>5</order></author></authors><documents><document><filename>71198__35903__be0e978de56c468bbc544b5b0b43a6dd.pdf</filename><originalFilename>Ademiloye et al._2026_Book Chapter_Accepted.pdf</originalFilename><uploaded>2026-01-06T10:44:30.9435772</uploaded><type>Output</type><contentLength>884048</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><copyrightCorrect>false</copyrightCorrect></document></documents><OutputDurs/></rfc1807>
spelling 2026-01-06T10:51:42.3764663 v2 71198 2026-01-06 Multiscale modeling of biomechanical properties of red blood cells e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false a667fc43fa020d8902e69ae71e5ad473 MOHAMMAD ABUGHABUSH MOHAMMAD ABUGHABUSH true false 2026-01-06 EAAS In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by different blood-related diseases such as malaria, sickle cell anemia and diabetes mellitus, they experience impaired deformability. Several experimental and numerical techniques have been proposed to elucidate the primary reasons for the observed impaired deformability and increased stiffening of RBC membrane. Multiscale modelling as a candidate numerical technique for this purpose is of particular interest since it incorporates more intrinsic details such as cellular architecture, microscale defects and substructural changes into its constitutive formulation, often resulting to improved accuracy and better computational efficiency. This chapter discusses some of the recent advances in multiscale modelling of the biomechanical properties of red blood cells. These advances include, among many others, efforts to accurately predict the biomechanical properties of healthy and diseased RBCs using a multiscale meshfree modelling framework. It also provides insights into how microstructural and temperature changes influence their deformability, pathogenesis, and pathophysiology. Furthermore, some perspectives on the multiscale modelling of biomechanical behaviors of RBCs are presented. Book chapter Recent Advances in Hemodynamics and Blood Mimetics 145 164 Elsevier 9780443240669 Computational Physiology; Multiscale modelling; Meshfree method; Biomechanical properties; Red blood cells; Malaria 1 1 2026 2026-01-01 10.1016/b978-0-443-24066-9.00008-8 https://doi.org/10.1016/b978-0-443-24066-9.00008-8 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2026-01-06T10:51:42.3764663 2026-01-06T10:27:03.7023703 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 Jorge Molina 2 MOHAMMAD ABUGHABUSH 3 Yang Zhang 4 Ping Xiang 5 71198__35903__be0e978de56c468bbc544b5b0b43a6dd.pdf Ademiloye et al._2026_Book Chapter_Accepted.pdf 2026-01-06T10:44:30.9435772 Output 884048 application/pdf Accepted Manuscript true false
title Multiscale modeling of biomechanical properties of red blood cells
spellingShingle Multiscale modeling of biomechanical properties of red blood cells
Adesola Ademiloye
MOHAMMAD ABUGHABUSH
title_short Multiscale modeling of biomechanical properties of red blood cells
title_full Multiscale modeling of biomechanical properties of red blood cells
title_fullStr Multiscale modeling of biomechanical properties of red blood cells
title_full_unstemmed Multiscale modeling of biomechanical properties of red blood cells
title_sort Multiscale modeling of biomechanical properties of red blood cells
author_id_str_mv e37960ed89a7e3eaeba2201762626594
a667fc43fa020d8902e69ae71e5ad473
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
a667fc43fa020d8902e69ae71e5ad473_***_MOHAMMAD ABUGHABUSH
author Adesola Ademiloye
MOHAMMAD ABUGHABUSH
author2 Adesola Ademiloye
Jorge Molina
MOHAMMAD ABUGHABUSH
Yang Zhang
Ping Xiang
format Book chapter
container_title Recent Advances in Hemodynamics and Blood Mimetics
container_start_page 145
publishDate 2026
institution Swansea University
isbn 9780443240669
doi_str_mv 10.1016/b978-0-443-24066-9.00008-8
publisher Elsevier
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url https://doi.org/10.1016/b978-0-443-24066-9.00008-8
document_store_str 1
active_str 0
description In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by different blood-related diseases such as malaria, sickle cell anemia and diabetes mellitus, they experience impaired deformability. Several experimental and numerical techniques have been proposed to elucidate the primary reasons for the observed impaired deformability and increased stiffening of RBC membrane. Multiscale modelling as a candidate numerical technique for this purpose is of particular interest since it incorporates more intrinsic details such as cellular architecture, microscale defects and substructural changes into its constitutive formulation, often resulting to improved accuracy and better computational efficiency. This chapter discusses some of the recent advances in multiscale modelling of the biomechanical properties of red blood cells. These advances include, among many others, efforts to accurately predict the biomechanical properties of healthy and diseased RBCs using a multiscale meshfree modelling framework. It also provides insights into how microstructural and temperature changes influence their deformability, pathogenesis, and pathophysiology. Furthermore, some perspectives on the multiscale modelling of biomechanical behaviors of RBCs are presented.
published_date 2026-01-01T05:34:50Z
_version_ 1856896489414983680
score 11.096068

Similar Items