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Multiscale modeling of biomechanical properties of red blood cells
Adesola Ademiloye 
,
Jorge Molina,
MOHAMMAD ABUGHABUSH,
Yang Zhang,
Ping Xiang
,
Jorge Molina,
MOHAMMAD ABUGHABUSH,
Yang Zhang,
Ping Xiang
Recent Advances in Hemodynamics and Blood Mimetics, Pages: 145 - 164
Swansea University Authors:
Adesola Ademiloye , MOHAMMAD ABUGHABUSH
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DOI (Published version): 10.1016/b978-0-443-24066-9.00008-8
Abstract
In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by...
| Published in: | Recent Advances in Hemodynamics and Blood Mimetics |
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| ISBN: | 9780443240669 |
| Published: |
Elsevier
2026
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| Online Access: |
https://doi.org/10.1016/b978-0-443-24066-9.00008-8 |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa71198 |
| Abstract: |
In recent decades, the biomechanical and biophysical properties of human red blood cells (RBCs) have been greatly explored by numerous researchers for diverse reasons. In normal physiological conditions, RBCs undergo large deformation when traversing thin microcapillaries, however, upon infection by different blood-related diseases such as malaria, sickle cell anemia and diabetes mellitus, they experience impaired deformability. Several experimental and numerical techniques have been proposed to elucidate the primary reasons for the observed impaired deformability and increased stiffening of RBC membrane. Multiscale modelling as a candidate numerical technique for this purpose is of particular interest since it incorporates more intrinsic details such as cellular architecture, microscale defects and substructural changes into its constitutive formulation, often resulting to improved accuracy and better computational efficiency. This chapter discusses some of the recent advances in multiscale modelling of the biomechanical properties of red blood cells. These advances include, among many others, efforts to accurately predict the biomechanical properties of healthy and diseased RBCs using a multiscale meshfree modelling framework. It also provides insights into how microstructural and temperature changes influence their deformability, pathogenesis, and pathophysiology. Furthermore, some perspectives on the multiscale modelling of biomechanical behaviors of RBCs are presented. |
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| Keywords: |
Computational Physiology; Multiscale modelling; Meshfree method; Biomechanical properties; Red blood cells; Malaria |
| College: |
Faculty of Science and Engineering |
| Start Page: |
145 |
| End Page: |
164 |