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Targeting DNA mismatches with metal complexes

Natalia Kolozsvari, Martin Gill Orcid Logo

Journal of Inorganic Biochemistry, Volume: 271, Start page: 112977

Swansea University Authors: Natalia Kolozsvari, Martin Gill Orcid Logo

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DOI (Published version): 10.1016/j.jinorgbio.2025.112977

Abstract

DNA mismatches are non Watson-Crick base pairs that arise from errors during replication or are the result of DNA damage. Normally repaired by the mismatch mediated repair (MMR) pathway, in cancers deficient in MMR, such as subsets of colorectal and endometrial cancers, mismatches persist and accumu...

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Published in: Journal of Inorganic Biochemistry
ISSN: 0162-0134 1873-3344
Published: Elsevier BV 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69837
first_indexed 2025-06-27T13:44:35Z
last_indexed 2025-07-13T03:19:38Z
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spelling 2025-07-11T15:32:38.2144089 v2 69837 2025-06-27 Targeting DNA mismatches with metal complexes 8e420c0021b2ede0cfa9cc8bda049ed3 Natalia Kolozsvari Natalia Kolozsvari true false 485d85b532851e8863cd19c6af7e00f7 0000-0002-1371-5676 Martin Gill Martin Gill true false 2025-06-27 EAAS DNA mismatches are non Watson-Crick base pairs that arise from errors during replication or are the result of DNA damage. Normally repaired by the mismatch mediated repair (MMR) pathway, in cancers deficient in MMR, such as subsets of colorectal and endometrial cancers, mismatches persist and accumulate, providing a biochemical vulnerability creating a target for small-molecule intervention. This review explores how metal complexes employing rhodium(III), ruthenium(II) or platinum(II) centres can exploit this molecular distinction to preferentially bind mismatch sites in DNA. We discuss the potential of this interaction to act as a foundation for next-generation therapeutics and imaging probes where the unique structural, electronic, and photophysical properties of metal complexes and associated ligand design offer opportunities to differentiate between canonical and mismatched DNA with high selectivity. Journal Article Journal of Inorganic Biochemistry 271 112977 Elsevier BV 0162-0134 1873-3344 Rhodium; Ruthenium; Platinum; Mismatch DNA; cancer; MMR deficient 1 10 2025 2025-10-01 10.1016/j.jinorgbio.2025.112977 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) This work was supported by Cancer Research Wales (Pritchard and Moore Scholarship, grant no. 2542). 2025-07-11T15:32:38.2144089 2025-06-27T14:41:34.0810451 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Natalia Kolozsvari 1 Martin Gill 0000-0002-1371-5676 2 69837__34748__744bf55670ef4e6b8f91e5060559ea8e.pdf 69837.VoR.pdf 2025-07-11T15:04:08.9296256 Output 6087831 application/pdf Version of Record true © 2025 The Authors. This is an open access article under the CC BY license. true eng http://creativecommons.org/licenses/by/4.0/
title Targeting DNA mismatches with metal complexes
spellingShingle Targeting DNA mismatches with metal complexes
Natalia Kolozsvari
Martin Gill
title_short Targeting DNA mismatches with metal complexes
title_full Targeting DNA mismatches with metal complexes
title_fullStr Targeting DNA mismatches with metal complexes
title_full_unstemmed Targeting DNA mismatches with metal complexes
title_sort Targeting DNA mismatches with metal complexes
author_id_str_mv 8e420c0021b2ede0cfa9cc8bda049ed3
485d85b532851e8863cd19c6af7e00f7
author_id_fullname_str_mv 8e420c0021b2ede0cfa9cc8bda049ed3_***_Natalia Kolozsvari
485d85b532851e8863cd19c6af7e00f7_***_Martin Gill
author Natalia Kolozsvari
Martin Gill
author2 Natalia Kolozsvari
Martin Gill
format Journal article
container_title Journal of Inorganic Biochemistry
container_volume 271
container_start_page 112977
publishDate 2025
institution Swansea University
issn 0162-0134
1873-3344
doi_str_mv 10.1016/j.jinorgbio.2025.112977
publisher Elsevier BV
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description DNA mismatches are non Watson-Crick base pairs that arise from errors during replication or are the result of DNA damage. Normally repaired by the mismatch mediated repair (MMR) pathway, in cancers deficient in MMR, such as subsets of colorectal and endometrial cancers, mismatches persist and accumulate, providing a biochemical vulnerability creating a target for small-molecule intervention. This review explores how metal complexes employing rhodium(III), ruthenium(II) or platinum(II) centres can exploit this molecular distinction to preferentially bind mismatch sites in DNA. We discuss the potential of this interaction to act as a foundation for next-generation therapeutics and imaging probes where the unique structural, electronic, and photophysical properties of metal complexes and associated ligand design offer opportunities to differentiate between canonical and mismatched DNA with high selectivity.
published_date 2025-10-01T05:30:48Z
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score 11.096295

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