Journal article 330 views 94 downloads
Targeting DNA mismatches with metal complexes
Journal of Inorganic Biochemistry, Volume: 271, Start page: 112977
Swansea University Authors:
Natalia Kolozsvari, Martin Gill
-
PDF | Version of Record
© 2025 The Authors. This is an open access article under the CC BY license.
Download (5.81MB)
DOI (Published version): 10.1016/j.jinorgbio.2025.112977
Abstract
DNA mismatches are non Watson-Crick base pairs that arise from errors during replication or are the result of DNA damage. Normally repaired by the mismatch mediated repair (MMR) pathway, in cancers deficient in MMR, such as subsets of colorectal and endometrial cancers, mismatches persist and accumu...
| Published in: | Journal of Inorganic Biochemistry |
|---|---|
| ISSN: | 0162-0134 1873-3344 |
| Published: |
Elsevier BV
2025
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa69837 |
| Abstract: |
DNA mismatches are non Watson-Crick base pairs that arise from errors during replication or are the result of DNA damage. Normally repaired by the mismatch mediated repair (MMR) pathway, in cancers deficient in MMR, such as subsets of colorectal and endometrial cancers, mismatches persist and accumulate, providing a biochemical vulnerability creating a target for small-molecule intervention. This review explores how metal complexes employing rhodium(III), ruthenium(II) or platinum(II) centres can exploit this molecular distinction to preferentially bind mismatch sites in DNA. We discuss the potential of this interaction to act as a foundation for next-generation therapeutics and imaging probes where the unique structural, electronic, and photophysical properties of metal complexes and associated ligand design offer opportunities to differentiate between canonical and mismatched DNA with high selectivity. |
|---|---|
| Keywords: |
Rhodium; Ruthenium; Platinum; Mismatch DNA; cancer; MMR deficient |
| College: |
Faculty of Science and Engineering |
| Funders: |
This work was supported by Cancer Research Wales (Pritchard and Moore Scholarship, grant no. 2542). |
| Start Page: |
112977 |