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Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study

Tamas Szakmany Orcid Logo, Rowena Bailey, Rowena Griffiths, Richard Pugh, Joseph Hollinghurst, Ashley Akbari Orcid Logo, Ronan Lyons

Journal of the Intensive Care Society

Swansea University Authors: Rowena Bailey, Rowena Griffiths, Joseph Hollinghurst, Ashley Akbari Orcid Logo, Ronan Lyons

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DOI (Published version): 10.1177/17511437251326774

Abstract

Background:We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.Methods:We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006–2018, with an inpatient...

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Published in: Journal of the Intensive Care Society
ISSN: 1751-1437 1751-1437
Published: SAGE Publications 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69131
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We included all adult patients, 2006&#x2013;2018, with an inpatient admission including one or more explicit sepsis codes.Results:38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients with high levels of comorbidities, but changes were consistent across all age groups, areas of deprivation and ICU admissions. Estimated inpatient sepsis costs were &#xA3;340.34&#x2009;million in total during the study period. The average cost per hospital spell was &#xA3;7270. Patients readmitted to the hospital for sepsis amassed estimated treatment costs of over &#xA3;72&#x2009;million during the study period. Out of the 38,564 persons, 21,275 (55.2%) died within 3&#x2009;years of their first admission. Inpatient mortality halved from 40.5% to 19.5%, and there was a trend towards reduced mortality at 6&#x2009;months, 1 and 3&#x2009;years post hospital discharge.Conclusion:Sepsis related hospital admissions are increasing over time and still likely to be underreported. 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This work was supported by the ADR Wales programme of work. ADR Wales is part of the Economic and Social Research Council (part of UK Research and Innovation) funded ADR UK (grant ES/S007393/1). 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spelling 2025-08-06T14:55:37.6318809 v2 69131 2025-03-21 Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study 455e2c1e6193448f6269b9e72acaf865 Rowena Bailey Rowena Bailey true false 381464f639f98bd388c29326ca7f862c Rowena Griffiths Rowena Griffiths true false d7c51b69270b644a11b904629fe56ab0 Joseph Hollinghurst Joseph Hollinghurst true false aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false 83efcf2a9dfcf8b55586999d3d152ac6 Ronan Lyons Ronan Lyons true false 2025-03-21 MEDS Background:We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.Methods:We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006–2018, with an inpatient admission including one or more explicit sepsis codes.Results:38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients with high levels of comorbidities, but changes were consistent across all age groups, areas of deprivation and ICU admissions. Estimated inpatient sepsis costs were £340.34 million in total during the study period. The average cost per hospital spell was £7270. Patients readmitted to the hospital for sepsis amassed estimated treatment costs of over £72 million during the study period. Out of the 38,564 persons, 21,275 (55.2%) died within 3 years of their first admission. Inpatient mortality halved from 40.5% to 19.5%, and there was a trend towards reduced mortality at 6 months, 1 and 3 years post hospital discharge.Conclusion:Sepsis related hospital admissions are increasing over time and still likely to be underreported. Although mortality appears to have fallen, prolonged hospitalisation and readmissions place a significant burden on healthcare system resources and costs. Journal Article Journal of the Intensive Care Society 0 SAGE Publications 1751-1437 1751-1437 16 3 2025 2025-03-16 10.1177/17511437251326774 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This work was supported by Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-9006) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. This work was supported by the ADR Wales programme of work. ADR Wales is part of the Economic and Social Research Council (part of UK Research and Innovation) funded ADR UK (grant ES/S007393/1). This work was supported by the All-Wales Critical Care and Trauma Network. 2025-08-06T14:55:37.6318809 2025-03-21T07:43:00.1785802 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Tamas Szakmany 0000-0003-3632-8844 1 Rowena Bailey 2 Rowena Griffiths 3 Richard Pugh 4 Joseph Hollinghurst 5 Ashley Akbari 0000-0003-0814-0801 6 Ronan Lyons 7 69131__33984__7e8e273678c6404282068c4c952a77bb.pdf 69131.VoR.pdf 2025-04-10T11:39:42.7972857 Output 541260 application/pdf Version of Record true © The Intensive Care Society 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License. true eng https://creativecommons.org/licenses/by/4.0/
title Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
spellingShingle Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
Rowena Bailey
Rowena Griffiths
Joseph Hollinghurst
Ashley Akbari
Ronan Lyons
title_short Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
title_full Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
title_fullStr Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
title_full_unstemmed Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
title_sort Admissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study
author_id_str_mv 455e2c1e6193448f6269b9e72acaf865
381464f639f98bd388c29326ca7f862c
d7c51b69270b644a11b904629fe56ab0
aa1b025ec0243f708bb5eb0a93d6fb52
83efcf2a9dfcf8b55586999d3d152ac6
author_id_fullname_str_mv 455e2c1e6193448f6269b9e72acaf865_***_Rowena Bailey
381464f639f98bd388c29326ca7f862c_***_Rowena Griffiths
d7c51b69270b644a11b904629fe56ab0_***_Joseph Hollinghurst
aa1b025ec0243f708bb5eb0a93d6fb52_***_Ashley Akbari
83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons
author Rowena Bailey
Rowena Griffiths
Joseph Hollinghurst
Ashley Akbari
Ronan Lyons
author2 Tamas Szakmany
Rowena Bailey
Rowena Griffiths
Richard Pugh
Joseph Hollinghurst
Ashley Akbari
Ronan Lyons
format Journal article
container_title Journal of the Intensive Care Society
container_volume 0
publishDate 2025
institution Swansea University
issn 1751-1437
1751-1437
doi_str_mv 10.1177/17511437251326774
publisher SAGE Publications
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
active_str 0
description Background:We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.Methods:We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006–2018, with an inpatient admission including one or more explicit sepsis codes.Results:38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients with high levels of comorbidities, but changes were consistent across all age groups, areas of deprivation and ICU admissions. Estimated inpatient sepsis costs were £340.34 million in total during the study period. The average cost per hospital spell was £7270. Patients readmitted to the hospital for sepsis amassed estimated treatment costs of over £72 million during the study period. Out of the 38,564 persons, 21,275 (55.2%) died within 3 years of their first admission. Inpatient mortality halved from 40.5% to 19.5%, and there was a trend towards reduced mortality at 6 months, 1 and 3 years post hospital discharge.Conclusion:Sepsis related hospital admissions are increasing over time and still likely to be underreported. Although mortality appears to have fallen, prolonged hospitalisation and readmissions place a significant burden on healthcare system resources and costs.
published_date 2025-03-16T05:27:22Z
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