Journal article 45 views
Is low‐dose glucagon needed and effective in preventing fasted exercise‐induced hypoglycaemia in type 1 diabetes treated with the MiniMed 780G, an automated insulin delivery system?
Sissel Banner Lundemose 
,
Olivia M. McCarthy,
Merete Bechmann Christensen,
Christian Laugesen ,
Richard Bracken ,
Jens Juul Holst ,
Ajenthen Gayathri Ranjan ,
Kirsten Nørgaard
,
Olivia M. McCarthy,
Merete Bechmann Christensen,
Christian Laugesen ,
Richard Bracken ,
Jens Juul Holst ,
Ajenthen Gayathri Ranjan ,
Kirsten Nørgaard
Diabetes, Obesity and Metabolism
Swansea University Author:
Richard Bracken
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1111/dom.16103
Abstract
Aim: To evaluate and compare the plasma glucose (PG) response during spontaneous fasted morning moderate‐intensity exercise with and without injection of subcutaneous glucagon in adults with type 1 diabetes (T1D) treated with an automated insulin delivery (AID) system. Methods: Ten adults (four fema...
| Published in: | Diabetes, Obesity and Metabolism |
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| ISSN: | 1462-8902 1463-1326 |
| Published: |
Wiley
2024
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68504 |
| Abstract: |
Aim: To evaluate and compare the plasma glucose (PG) response during spontaneous fasted morning moderate‐intensity exercise with and without injection of subcutaneous glucagon in adults with type 1 diabetes (T1D) treated with an automated insulin delivery (AID) system. Methods: Ten adults (four female) with T1D (age 50 [42–67] years, diabetes duration: 22 [14–44] years, HbA1c: 55 [47–69] mmol/mol) treated with the MiniMed™ 780G AID system participated in a proof‐of‐concept two‐period, crossover trial. Fasting participants undertook a 45 min bout of continuous moderate‐intensity (~60% V̇O2peak) exercise on a cycle ergometer followed by 1 h of rest. Before exercise, 150‐μg glucagon was administered subcutaneously on visit 1 (GLUC) but not on visit 2 (NO‐GLUC). Temporary target on the AID was activated 15 min before until 15 min after exercise cessation. Blood samples were taken at 5‐ and 15‐min intervals for measuring PG and biomarkers. Data were analysed using paired t tests or repeated measures ANOVA. Results: Time in range (3.9–10.0 mmol/L) was 100% on both study visits. No hypoglycaemia (<3.9 mmol/L) occurred in either arm. The GLUC arm had significantly higher mean PG (p = 0.01), area under the PG curve (p = 0.01), coefficient of variation (p < 0.01), peak PG (p = 0.01) and PG at the end of exercise (p < 0.01). No differences in endogenous glucoregulatory hormones were observed between visits. Conclusion: Adults with T1D treated with the MiniMed™ 780G can perform spontaneous fasted moderate‐intensity exercise without hypoglycaemia. Therefore, glucagon was not needed for prevention of hypoglycaemia in such situations. |
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| Keywords: |
Artificial pancreas, hybrid closed loop, hypoglycaemia rescue and physical activity |
| College: |
Faculty of Science and Engineering |
| Funders: |
This project received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. |