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Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
MicrobiologyOpen, Volume: 13, Issue: 6, Start page: e011
Swansea University Author:
Gilda Padalino
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DOI (Published version): 10.1002/mbo3.70011
Abstract
Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and...
Published in: | MicrobiologyOpen |
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ISSN: | 2045-8827 2045-8827 |
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Wiley
2024
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URI: | https://cronfa.swan.ac.uk/Record/cronfa68407 |
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2025-02-04T14:21:16.4961870 v2 68407 2024-12-02 Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms 7e5526209f02734f57ba19b0d17604ec 0000-0001-8580-1293 Gilda Padalino Gilda Padalino true false 2024-12-02 MEDS Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents. Journal Article MicrobiologyOpen 13 6 e011 Wiley 2045-8827 2045-8827 Biofilm, Enterococcus faecalis, Enterococcus faecium, MRSA, quinoxaline, Staphylococcus aureus, VRE 12 12 2024 2024-12-12 10.1002/mbo3.70011 Commentary COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) This work was supported by Aberystwyth University (Technology Transfer Grant Development Award) and the Life Sciences Wales Research Network (a Welsh Government Ser Cymru initiative). 2025-02-04T14:21:16.4961870 2024-12-02T10:16:27.2896989 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Gilda Padalino 0000-0001-8580-1293 1 Katrina Duggan 2 Luis A. J. Mur 3 Jean‐Yves Maillard 0000-0002-8617-9288 4 Andrea Brancale 5 Karl F. Hoffmann 6 68407__33153__0a3845d6571f432298c6832acf025b62.pdf 68407.VOR.pdf 2024-12-17T10:56:52.0046174 Output 2772849 application/pdf Version of Record true © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/ |
title |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
spellingShingle |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms Gilda Padalino |
title_short |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
title_full |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
title_fullStr |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
title_full_unstemmed |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
title_sort |
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms |
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7e5526209f02734f57ba19b0d17604ec |
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7e5526209f02734f57ba19b0d17604ec_***_Gilda Padalino |
author |
Gilda Padalino |
author2 |
Gilda Padalino Katrina Duggan Luis A. J. Mur Jean‐Yves Maillard Andrea Brancale Karl F. Hoffmann |
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MicrobiologyOpen |
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10.1002/mbo3.70011 |
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Wiley |
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Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents. |
published_date |
2024-12-12T07:39:00Z |
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11.067306 |