Journal article 236 views 48 downloads

Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

Gilda Padalino Orcid Logo, Katrina Duggan, Luis A. J. Mur, Jean‐Yves Maillard Orcid Logo, Andrea Brancale, Karl F. Hoffmann

MicrobiologyOpen, Volume: 13, Issue: 6, Start page: e011

Swansea University Author: Gilda Padalino Orcid Logo

  • 68407.VOR.pdf

    PDF | Version of Record

    © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0).

    Download (2.64MB)

Check full text

DOI (Published version): 10.1002/mbo3.70011

Abstract

Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and...

Full description

Published in: MicrobiologyOpen
ISSN: 2045-8827 2045-8827
Published: Wiley 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa68407
first_indexed 2024-12-02T13:47:18Z
last_indexed 2025-02-04T20:27:04Z
id cronfa68407
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-02-04T14:21:16.4961870</datestamp><bib-version>v2</bib-version><id>68407</id><entry>2024-12-02</entry><title>Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms</title><swanseaauthors><author><sid>7e5526209f02734f57ba19b0d17604ec</sid><ORCID>0000-0001-8580-1293</ORCID><firstname>Gilda</firstname><surname>Padalino</surname><name>Gilda Padalino</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-12-02</date><deptcode>MEDS</deptcode><abstract>Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1&#x2009;mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.</abstract><type>Journal Article</type><journal>MicrobiologyOpen</journal><volume>13</volume><journalNumber>6</journalNumber><paginationStart>e011</paginationStart><paginationEnd/><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>2045-8827</issnPrint><issnElectronic>2045-8827</issnElectronic><keywords>Biofilm, Enterococcus faecalis, Enterococcus faecium, MRSA, quinoxaline, Staphylococcus aureus, VRE</keywords><publishedDay>12</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-12-12</publishedDate><doi>10.1002/mbo3.70011</doi><url/><notes>Commentary</notes><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>This work was supported by Aberystwyth University (Technology Transfer Grant Development Award) and the Life Sciences Wales Research Network (a Welsh Government Ser Cymru initiative).</funders><projectreference/><lastEdited>2025-02-04T14:21:16.4961870</lastEdited><Created>2024-12-02T10:16:27.2896989</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Pharmacy</level></path><authors><author><firstname>Gilda</firstname><surname>Padalino</surname><orcid>0000-0001-8580-1293</orcid><order>1</order></author><author><firstname>Katrina</firstname><surname>Duggan</surname><order>2</order></author><author><firstname>Luis A. J.</firstname><surname>Mur</surname><order>3</order></author><author><firstname>Jean&#x2010;Yves</firstname><surname>Maillard</surname><orcid>0000-0002-8617-9288</orcid><order>4</order></author><author><firstname>Andrea</firstname><surname>Brancale</surname><order>5</order></author><author><firstname>Karl F.</firstname><surname>Hoffmann</surname><order>6</order></author></authors><documents><document><filename>68407__33153__0a3845d6571f432298c6832acf025b62.pdf</filename><originalFilename>68407.VOR.pdf</originalFilename><uploaded>2024-12-17T10:56:52.0046174</uploaded><type>Output</type><contentLength>2772849</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-02-04T14:21:16.4961870 v2 68407 2024-12-02 Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms 7e5526209f02734f57ba19b0d17604ec 0000-0001-8580-1293 Gilda Padalino Gilda Padalino true false 2024-12-02 MEDS Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents. Journal Article MicrobiologyOpen 13 6 e011 Wiley 2045-8827 2045-8827 Biofilm, Enterococcus faecalis, Enterococcus faecium, MRSA, quinoxaline, Staphylococcus aureus, VRE 12 12 2024 2024-12-12 10.1002/mbo3.70011 Commentary COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) This work was supported by Aberystwyth University (Technology Transfer Grant Development Award) and the Life Sciences Wales Research Network (a Welsh Government Ser Cymru initiative). 2025-02-04T14:21:16.4961870 2024-12-02T10:16:27.2896989 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Gilda Padalino 0000-0001-8580-1293 1 Katrina Duggan 2 Luis A. J. Mur 3 Jean‐Yves Maillard 0000-0002-8617-9288 4 Andrea Brancale 5 Karl F. Hoffmann 6 68407__33153__0a3845d6571f432298c6832acf025b62.pdf 68407.VOR.pdf 2024-12-17T10:56:52.0046174 Output 2772849 application/pdf Version of Record true © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
spellingShingle Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
Gilda Padalino
title_short Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
title_full Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
title_fullStr Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
title_full_unstemmed Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
title_sort Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
author_id_str_mv 7e5526209f02734f57ba19b0d17604ec
author_id_fullname_str_mv 7e5526209f02734f57ba19b0d17604ec_***_Gilda Padalino
author Gilda Padalino
author2 Gilda Padalino
Katrina Duggan
Luis A. J. Mur
Jean‐Yves Maillard
Andrea Brancale
Karl F. Hoffmann
format Journal article
container_title MicrobiologyOpen
container_volume 13
container_issue 6
container_start_page e011
publishDate 2024
institution Swansea University
issn 2045-8827
2045-8827
doi_str_mv 10.1002/mbo3.70011
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str 1
active_str 0
description Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.
published_date 2024-12-12T07:39:00Z
_version_ 1836697403140341760
score 11.067306