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Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

Gilda Padalino Orcid Logo, Katrina Duggan, Luis A. J. Mur, Jean‐Yves Maillard Orcid Logo, Andrea Brancale, Karl F. Hoffmann

MicrobiologyOpen, Volume: 13, Issue: 6, Start page: e011

Swansea University Author: Gilda Padalino Orcid Logo

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DOI (Published version): 10.1002/mbo3.70011

Abstract

Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and...

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Published in: MicrobiologyOpen
ISSN: 2045-8827 2045-8827
Published: Wiley 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68407
Abstract: Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.
Item Description: Commentary
Keywords: Biofilm, Enterococcus faecalis, Enterococcus faecium, MRSA, quinoxaline, Staphylococcus aureus, VRE
College: Faculty of Medicine, Health and Life Sciences
Funders: This work was supported by Aberystwyth University (Technology Transfer Grant Development Award) and the Life Sciences Wales Research Network (a Welsh Government Ser Cymru initiative).
Issue: 6
Start Page: e011

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