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Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK

Ayodele Opatola, Mike Seaborne Orcid Logo, Jonathan Kennedy, Dyfrig Hughes, Hamish Laing Orcid Logo, Rhiannon Owen Orcid Logo, David Tuthill Orcid Logo, Robert Bracchi, Sinead Brophy Orcid Logo

BMJ Paediatrics Open, Volume: 8, Issue: 1, Start page: e002831

Swansea University Authors: Ayodele Opatola, Mike Seaborne Orcid Logo, Jonathan Kennedy, Hamish Laing Orcid Logo, Rhiannon Owen Orcid Logo, Sinead Brophy Orcid Logo

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DOI (Published version): 10.1136/bmjpo-2024-002831

Abstract

Objective: To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was perfor...

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Published in: BMJ Paediatrics Open
ISSN: 2399-9772
Published: BMJ Publishing Group Ltd 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68161
first_indexed 2024-11-04T15:42:17Z
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Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was performed using Wales health data, extracted from the SAIL (Secure Anonymised Information Linkage) databank. Inclusion: Children (0&#x2013;12 years) prescribed oral antibiotics by their GP in Wales. Exposure: Antibiotic prescription (penicillins, cephalosporins, macrolides, dihydropyrimidines, nitroimidazoles, nitrofurans, lincosamides). Outcome: Adverse event as defined by; patients&#x2019; death within 5&#x2009;days, records of emergency admission within 5&#x2009;days and GP records of adverse drug reactions or prescription of another antibiotic within 14 days. Analysis: Logistic regression of adverse events versus no adverse events at follow-up time. Results: There were 139&#x2009;571 prescriptions of the selected antibiotics and 71&#x2009;541 children (51.39% male) included with follow-up data of which there were 25&#x2009;445 (18.23% of all prescriptions) children experienced adverse outcomes. There was higher odds of adverse events for lower weight children and those who were younger, female, of Asian origin or deprived. Conclusion: The findings support the hypothesis that smaller children for their age (eg, low weight, female, Asian) are more likely to experience adverse events following antibiotics prescription. 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spelling 2024-12-11T13:45:21.6097629 v2 68161 2024-11-04 Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK 10c8df3a2b50d4f29ec5ac35bafb41ff Ayodele Opatola Ayodele Opatola true false fcc7ece0f04577ad5f283b00dd7f52cf 0000-0002-4921-7556 Mike Seaborne Mike Seaborne true false 08163d1f58d7fefcb1c695bcc2e0ef68 Jonathan Kennedy Jonathan Kennedy true false be60df55bc8e44cf2aacf7230876588d 0000-0002-5661-7937 Hamish Laing Hamish Laing true false 0d30aa00eef6528f763a1e1589f703ec 0000-0001-5977-376X Rhiannon Owen Rhiannon Owen true false 84f5661b35a729f55047f9e793d8798b 0000-0001-7417-2858 Sinead Brophy Sinead Brophy true false 2024-11-04 MEDS Objective: To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was performed using Wales health data, extracted from the SAIL (Secure Anonymised Information Linkage) databank. Inclusion: Children (0–12 years) prescribed oral antibiotics by their GP in Wales. Exposure: Antibiotic prescription (penicillins, cephalosporins, macrolides, dihydropyrimidines, nitroimidazoles, nitrofurans, lincosamides). Outcome: Adverse event as defined by; patients’ death within 5 days, records of emergency admission within 5 days and GP records of adverse drug reactions or prescription of another antibiotic within 14 days. Analysis: Logistic regression of adverse events versus no adverse events at follow-up time. Results: There were 139 571 prescriptions of the selected antibiotics and 71 541 children (51.39% male) included with follow-up data of which there were 25 445 (18.23% of all prescriptions) children experienced adverse outcomes. There was higher odds of adverse events for lower weight children and those who were younger, female, of Asian origin or deprived. Conclusion: The findings support the hypothesis that smaller children for their age (eg, low weight, female, Asian) are more likely to experience adverse events following antibiotics prescription. This work suggests child weight, in addition to age, should be used when prescribing antibiotics to children in primary care. Journal Article BMJ Paediatrics Open 8 1 e002831 BMJ Publishing Group Ltd 2399-9772 28 11 2024 2024-11-28 10.1136/bmjpo-2024-002831 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) This work was supported by Health Data Research UK (Site award number: HDRUK2023.0019), which is funded by the Medical Research Council (UKRI), the National Institute for Health Research, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council (UKRI), the Engineering and Physical Sciences Research Council (UKRI), Health and Care Research Wales, Chief Scientist Office of the Scottish Government Health and Social Care Directorates, and Health and Social Care Research and Development Division (Public Health Agency, Northern Ireland). 2024-12-11T13:45:21.6097629 2024-11-04T15:35:18.4052638 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Ayodele Opatola 1 Mike Seaborne 0000-0002-4921-7556 2 Jonathan Kennedy 3 Dyfrig Hughes 4 Hamish Laing 0000-0002-5661-7937 5 Rhiannon Owen 0000-0001-5977-376X 6 David Tuthill 0000-0003-0190-0273 7 Robert Bracchi 8 Sinead Brophy 0000-0001-7417-2858 9
title Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
spellingShingle Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
Ayodele Opatola
Mike Seaborne
Jonathan Kennedy
Hamish Laing
Rhiannon Owen
Sinead Brophy
title_short Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
title_full Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
title_fullStr Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
title_full_unstemmed Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
title_sort Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
author_id_str_mv 10c8df3a2b50d4f29ec5ac35bafb41ff
fcc7ece0f04577ad5f283b00dd7f52cf
08163d1f58d7fefcb1c695bcc2e0ef68
be60df55bc8e44cf2aacf7230876588d
0d30aa00eef6528f763a1e1589f703ec
84f5661b35a729f55047f9e793d8798b
author_id_fullname_str_mv 10c8df3a2b50d4f29ec5ac35bafb41ff_***_Ayodele Opatola
fcc7ece0f04577ad5f283b00dd7f52cf_***_Mike Seaborne
08163d1f58d7fefcb1c695bcc2e0ef68_***_Jonathan Kennedy
be60df55bc8e44cf2aacf7230876588d_***_Hamish Laing
0d30aa00eef6528f763a1e1589f703ec_***_Rhiannon Owen
84f5661b35a729f55047f9e793d8798b_***_Sinead Brophy
author Ayodele Opatola
Mike Seaborne
Jonathan Kennedy
Hamish Laing
Rhiannon Owen
Sinead Brophy
author2 Ayodele Opatola
Mike Seaborne
Jonathan Kennedy
Dyfrig Hughes
Hamish Laing
Rhiannon Owen
David Tuthill
Robert Bracchi
Sinead Brophy
format Journal article
container_title BMJ Paediatrics Open
container_volume 8
container_issue 1
container_start_page e002831
publishDate 2024
institution Swansea University
issn 2399-9772
doi_str_mv 10.1136/bmjpo-2024-002831
publisher BMJ Publishing Group Ltd
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 0
active_str 0
description Objective: To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was performed using Wales health data, extracted from the SAIL (Secure Anonymised Information Linkage) databank. Inclusion: Children (0–12 years) prescribed oral antibiotics by their GP in Wales. Exposure: Antibiotic prescription (penicillins, cephalosporins, macrolides, dihydropyrimidines, nitroimidazoles, nitrofurans, lincosamides). Outcome: Adverse event as defined by; patients’ death within 5 days, records of emergency admission within 5 days and GP records of adverse drug reactions or prescription of another antibiotic within 14 days. Analysis: Logistic regression of adverse events versus no adverse events at follow-up time. Results: There were 139 571 prescriptions of the selected antibiotics and 71 541 children (51.39% male) included with follow-up data of which there were 25 445 (18.23% of all prescriptions) children experienced adverse outcomes. There was higher odds of adverse events for lower weight children and those who were younger, female, of Asian origin or deprived. Conclusion: The findings support the hypothesis that smaller children for their age (eg, low weight, female, Asian) are more likely to experience adverse events following antibiotics prescription. This work suggests child weight, in addition to age, should be used when prescribing antibiotics to children in primary care.
published_date 2024-11-28T08:36:01Z
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score 11.212735

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