Journal article 14 views
Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK
,
Jonathan Kennedy,
Dyfrig Hughes,
Hamish Laing ,
Rhiannon Owen ,
David Tuthill ,
Robert Bracchi,
Sinead Brophy
BMJ Paediatrics Open, Volume: 8, Issue: 1, Start page: e002831
Swansea University Authors:
Ayodele Opatola, Mike Seaborne , Jonathan Kennedy, Hamish Laing , Rhiannon Owen , Sinead Brophy
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1136/bmjpo-2024-002831
Abstract
Objective: To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was perfor...
| Published in: | BMJ Paediatrics Open |
|---|---|
| ISSN: | 2399-9772 |
| Published: |
BMJ Publishing Group Ltd
2024
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa68161 |
| Abstract: |
Objective: To examine if the weight of a child determines adverse events following oral antibiotics prescription. Design: Population respective cohort using linked general practice (GP), hospital data and linkage with the Welsh Demographic Service for demographic information. Data linkage was performed using Wales health data, extracted from the SAIL (Secure Anonymised Information Linkage) databank. Inclusion: Children (0–12 years) prescribed oral antibiotics by their GP in Wales. Exposure: Antibiotic prescription (penicillins, cephalosporins, macrolides, dihydropyrimidines, nitroimidazoles, nitrofurans, lincosamides). Outcome: Adverse event as defined by; patients’ death within 5 days, records of emergency admission within 5 days and GP records of adverse drug reactions or prescription of another antibiotic within 14 days. Analysis: Logistic regression of adverse events versus no adverse events at follow-up time. Results: There were 139 571 prescriptions of the selected antibiotics and 71 541 children (51.39% male) included with follow-up data of which there were 25 445 (18.23% of all prescriptions) children experienced adverse outcomes. There was higher odds of adverse events for lower weight children and those who were younger, female, of Asian origin or deprived. Conclusion: The findings support the hypothesis that smaller children for their age (eg, low weight, female, Asian) are more likely to experience adverse events following antibiotics prescription. This work suggests child weight, in addition to age, should be used when prescribing antibiotics to children in primary care. |
|---|---|
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by Health Data Research UK (Site award number: HDRUK2023.0019), which is funded by the Medical Research Council (UKRI), the National Institute for Health Research, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council (UKRI), the Engineering and Physical Sciences Research Council (UKRI), Health and Care Research Wales, Chief Scientist Office of the Scottish Government Health and Social Care Directorates, and Health and Social Care Research and Development Division (Public Health Agency, Northern Ireland). |
| Issue: |
1 |
| Start Page: |
e002831 |