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Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis

Sean Scully, Hywel Evans Orcid Logo, Sara Hatam, Sarah Cook, Hannah Whittaker, Costantinos Kallis, Ian Farr, Chris Orton Orcid Logo, Aziz Sheikh, Jennifer Quint

International Journal of Population Data Science, Volume: 9, Issue: 5

Swansea University Authors: Sean Scully, Hywel Evans Orcid Logo, Ian Farr, Chris Orton Orcid Logo

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DOI (Published version): 10.23889/ijpds.v9i5.2723

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ObjectiveThis study aimed to create harmonised datasets for asthma, chronic obstructive pulmonary disease (COPD), and Interstitial Lung Disease (ILD), and subsequently use them to calculate the incidence and prevalence of these diseases across three UK nations (England, Wales, and South-East Scotlan...

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Published in: International Journal of Population Data Science
ISSN: 2399-4908
Published: Swansea University 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68117
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spelling 2024-12-17T12:58:07.9740350 v2 68117 2024-10-30 Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis 7d578c07f0f506fa6e2255af54555ddc Sean Scully Sean Scully true false 73cc98a5b8e4122fdfcee5d88208b0b7 0000-0001-6745-4187 Hywel Evans Hywel Evans true false 3c02e7e9c2b064ee3e96e83b9777dde4 Ian Farr Ian Farr true false 555c622e1f7bd9d2e0341f2ebbfd3e7f 0000-0002-9561-2493 Chris Orton Chris Orton true false 2024-10-30 MEDS ObjectiveThis study aimed to create harmonised datasets for asthma, chronic obstructive pulmonary disease (COPD), and Interstitial Lung Disease (ILD), and subsequently use them to calculate the incidence and prevalence of these diseases across three UK nations (England, Wales, and South-East Scotland).ApproachHarmonised research-ready datasets were created using three electronic healthcare record databases. Records were selected between 01/01/2004 and 31/12/2019, with yearly age and sex standardised incidence and prevalence rates calculated.ResultsIn 2019, the incidence rates for asthma were: England, 0.89 (95%CI: 0.88–0.90); Wales, 0.66 (0.65–0.68); and South-East Scotland, 0.67 (0.64–0.71), which were all lower than in 2004. Incidence rates of COPD in England were 0.83 (0.82–0.85) and 0.67 (0.65–0.69) in Wales, which were both lower than in 2004, but Scotland remained similar at 1.06 (0.99–1.13). Incidence rates of ILD were: England, 3.27 (3.05–3.50); Wales, 1.39 (1.27–1.53); and Scotland, 1.63 (1.36–1.95), which were all higher than in 2004. Between 2004 and 2019, the prevalence of all three diseases increased across all three nations.ConclusionsSolving differences in coding between CPRD, SAIL Databank, and DataLoch databases enabled comparable cohorts to be created and the first harmonised UK estimates of incidence and prevalence for asthma, ILD, and COPD.ImplicationsHarmonised studies of asthma, COPD, and ILD across the UK can now be performed. The code produced is publicly available to facilitate future research, which can be adapted for other conditions and databases. Journal Article International Journal of Population Data Science 9 5 Swansea University 2399-4908 10 9 2024 2024-09-10 10.23889/ijpds.v9i5.2723 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2024-12-17T12:58:07.9740350 2024-10-30T11:46:00.3952939 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Sean Scully 1 Hywel Evans 0000-0001-6745-4187 2 Sara Hatam 3 Sarah Cook 4 Hannah Whittaker 5 Costantinos Kallis 6 Ian Farr 7 Chris Orton 0000-0002-9561-2493 8 Aziz Sheikh 9 Jennifer Quint 10
title Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
spellingShingle Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
Sean Scully
Hywel Evans
Ian Farr
Chris Orton
title_short Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
title_full Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
title_fullStr Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
title_full_unstemmed Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
title_sort Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis
author_id_str_mv 7d578c07f0f506fa6e2255af54555ddc
73cc98a5b8e4122fdfcee5d88208b0b7
3c02e7e9c2b064ee3e96e83b9777dde4
555c622e1f7bd9d2e0341f2ebbfd3e7f
author_id_fullname_str_mv 7d578c07f0f506fa6e2255af54555ddc_***_Sean Scully
73cc98a5b8e4122fdfcee5d88208b0b7_***_Hywel Evans
3c02e7e9c2b064ee3e96e83b9777dde4_***_Ian Farr
555c622e1f7bd9d2e0341f2ebbfd3e7f_***_Chris Orton
author Sean Scully
Hywel Evans
Ian Farr
Chris Orton
author2 Sean Scully
Hywel Evans
Sara Hatam
Sarah Cook
Hannah Whittaker
Costantinos Kallis
Ian Farr
Chris Orton
Aziz Sheikh
Jennifer Quint
format Journal article
container_title International Journal of Population Data Science
container_volume 9
container_issue 5
publishDate 2024
institution Swansea University
issn 2399-4908
doi_str_mv 10.23889/ijpds.v9i5.2723
publisher Swansea University
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 0
active_str 0
description ObjectiveThis study aimed to create harmonised datasets for asthma, chronic obstructive pulmonary disease (COPD), and Interstitial Lung Disease (ILD), and subsequently use them to calculate the incidence and prevalence of these diseases across three UK nations (England, Wales, and South-East Scotland).ApproachHarmonised research-ready datasets were created using three electronic healthcare record databases. Records were selected between 01/01/2004 and 31/12/2019, with yearly age and sex standardised incidence and prevalence rates calculated.ResultsIn 2019, the incidence rates for asthma were: England, 0.89 (95%CI: 0.88–0.90); Wales, 0.66 (0.65–0.68); and South-East Scotland, 0.67 (0.64–0.71), which were all lower than in 2004. Incidence rates of COPD in England were 0.83 (0.82–0.85) and 0.67 (0.65–0.69) in Wales, which were both lower than in 2004, but Scotland remained similar at 1.06 (0.99–1.13). Incidence rates of ILD were: England, 3.27 (3.05–3.50); Wales, 1.39 (1.27–1.53); and Scotland, 1.63 (1.36–1.95), which were all higher than in 2004. Between 2004 and 2019, the prevalence of all three diseases increased across all three nations.ConclusionsSolving differences in coding between CPRD, SAIL Databank, and DataLoch databases enabled comparable cohorts to be created and the first harmonised UK estimates of incidence and prevalence for asthma, ILD, and COPD.ImplicationsHarmonised studies of asthma, COPD, and ILD across the UK can now be performed. The code produced is publicly available to facilitate future research, which can be adapted for other conditions and databases.
published_date 2024-09-10T20:35:38Z
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