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Incidence and prevalence of asthma, COPD, and ILD across England, Wales, and South-East Scotland – a harmonised approach to data analysis

Sean Scully, Hywel Evans Orcid Logo, Sara Hatam, Sarah Cook, Hannah Whittaker, Costantinos Kallis, Ian Farr, Chris Orton Orcid Logo, Aziz Sheikh, Jennifer Quint

International Journal of Population Data Science, Volume: 9, Issue: 5

Swansea University Authors: Sean Scully, Hywel Evans Orcid Logo, Ian Farr, Chris Orton Orcid Logo

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Abstract

ObjectiveThis study aimed to create harmonised datasets for asthma, chronic obstructive pulmonary disease (COPD), and Interstitial Lung Disease (ILD), and subsequently use them to calculate the incidence and prevalence of these diseases across three UK nations (England, Wales, and South-East Scotlan...

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Published in: International Journal of Population Data Science
ISSN: 2399-4908
Published: Swansea University 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa68117
Abstract: ObjectiveThis study aimed to create harmonised datasets for asthma, chronic obstructive pulmonary disease (COPD), and Interstitial Lung Disease (ILD), and subsequently use them to calculate the incidence and prevalence of these diseases across three UK nations (England, Wales, and South-East Scotland).ApproachHarmonised research-ready datasets were created using three electronic healthcare record databases. Records were selected between 01/01/2004 and 31/12/2019, with yearly age and sex standardised incidence and prevalence rates calculated.ResultsIn 2019, the incidence rates for asthma were: England, 0.89 (95%CI: 0.88–0.90); Wales, 0.66 (0.65–0.68); and South-East Scotland, 0.67 (0.64–0.71), which were all lower than in 2004. Incidence rates of COPD in England were 0.83 (0.82–0.85) and 0.67 (0.65–0.69) in Wales, which were both lower than in 2004, but Scotland remained similar at 1.06 (0.99–1.13). Incidence rates of ILD were: England, 3.27 (3.05–3.50); Wales, 1.39 (1.27–1.53); and Scotland, 1.63 (1.36–1.95), which were all higher than in 2004. Between 2004 and 2019, the prevalence of all three diseases increased across all three nations.ConclusionsSolving differences in coding between CPRD, SAIL Databank, and DataLoch databases enabled comparable cohorts to be created and the first harmonised UK estimates of incidence and prevalence for asthma, ILD, and COPD.ImplicationsHarmonised studies of asthma, COPD, and ILD across the UK can now be performed. The code produced is publicly available to facilitate future research, which can be adapted for other conditions and databases.
College: Faculty of Medicine, Health and Life Sciences
Issue: 5