Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy

Velthuis, Jaap; Li, Yutong; Pritchard, Jordan; Sio, Chiara De; Beck, Lana; Hugtenburg, Richard

doi:10.3390/s23041799

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Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy

Jaap Velthuis, Yutong Li

, Jordan Pritchard

, Chiara De Sio

, Lana Beck

, Richard Hugtenburg

Sensors, Volume: 23, Issue: 4, Start page: 1799

Swansea University Authors: Jaap Velthuis, Richard Hugtenburg

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DOI (Published version): 10.3390/s23041799

Abstract

Intensity-modulated radiotherapy is a widely used technique for accurately targeting cancerous tumours in difficult locations using dynamically shaped beams. This is ideally accompanied by real-time independent verification. Monolithic active pixel sensors are a viable candidate for providing upstre...

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Published in:	Sensors
ISSN:	1424-8220
Published:	MDPI AG 2023
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa67935

first_indexed	2024-10-08T10:01:53Z
last_indexed	2024-11-25T14:21:07Z
id	cronfa67935
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spelling	2024-11-07T11:57:30.6151978 v2 67935 2024-10-08 Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy e781802af57442339d29ab1fa6156d25 Jaap Velthuis Jaap Velthuis true false efd2f52ea19cb047e01a01e6fa6fa54c 0000-0003-0352-9607 Richard Hugtenburg Richard Hugtenburg true false 2024-10-08 Intensity-modulated radiotherapy is a widely used technique for accurately targeting cancerous tumours in difficult locations using dynamically shaped beams. This is ideally accompanied by real-time independent verification. Monolithic active pixel sensors are a viable candidate for providing upstream beam monitoring during treatment. We have already demonstrated that a Monolithic Active Pixel Sensor (MAPS)-based system can fulfill all clinical requirements except for the minimum required size. Here, we report the performance of a large-scale demonstrator system consisting of a matrix of 2 × 2 sensors, which is large enough to cover almost all radiotherapy treatment fields when affixed to the shadow tray of the LINAC head. When building a matrix structure, a small dead area is inevitable. Here, we report that with a newly developed position algorithm, leaf positions can be reconstructed over the entire range with a position resolution of below ∼200 μm in the centre of the sensor, which worsens to just below 300 μm in the middle of the gap between two sensors. A leaf position resolution below 300 μm results in a dose error below 2%, which is good enough for clinical deployment. Journal Article Sensors 23 4 1799 MDPI AG 1424-8220 X-ray detectors; solid-state detectors; radiation-hard detectors; image processing; data processing methods; image reconstruction in medical imaging; radiotherapy concepts; radiotherapy verification; radiotherapy monitoring; detector alignment and calibration; Multi Leaf Collimator (MLC); Monolithic Active Pixel Sensors (MAPS) 6 2 2023 2023-02-06 10.3390/s23041799 COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee This research was funded by STFC and EPSRC through the IAA route. Jordan Pritchard received a scholarship from the EPSRC DTA. Yutong Li is funded by the Chinese Scholarship Council. 2024-11-07T11:57:30.6151978 2024-10-08T11:01:20.9594655 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medical Physics Jaap Velthuis 1 Yutong Li 0000-0003-2221-7983 2 Jordan Pritchard 0000-0002-2842-6615 3 Chiara De Sio 0000-0001-9112-425x 4 Lana Beck 0000-0003-4369-7648 5 Richard Hugtenburg 0000-0003-0352-9607 6 67935__32874__a22b34129c3649a88d2506e598b63d0c.pdf 67935.VoR.pdf 2024-11-07T11:56:23.6150140 Output 4465710 application/pdf Version of Record true Copyright: © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
spellingShingle	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy Jaap Velthuis Richard Hugtenburg
title_short	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
title_full	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
title_fullStr	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
title_full_unstemmed	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
title_sort	Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy
author_id_str_mv	e781802af57442339d29ab1fa6156d25 efd2f52ea19cb047e01a01e6fa6fa54c
author_id_fullname_str_mv	e781802af57442339d29ab1fa6156d25_*_Jaap Velthuis efd2f52ea19cb047e01a01e6fa6fa54c_*_Richard Hugtenburg
author	Jaap Velthuis Richard Hugtenburg
author2	Jaap Velthuis Yutong Li Jordan Pritchard Chiara De Sio Lana Beck Richard Hugtenburg
format	Journal article
container_title	Sensors
container_volume	23
container_issue	4
container_start_page	1799
publishDate	2023
institution	Swansea University
issn	1424-8220
doi_str_mv	10.3390/s23041799
publisher	MDPI AG
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medical Physics{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medical Physics
document_store_str	0
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description	Intensity-modulated radiotherapy is a widely used technique for accurately targeting cancerous tumours in difficult locations using dynamically shaped beams. This is ideally accompanied by real-time independent verification. Monolithic active pixel sensors are a viable candidate for providing upstream beam monitoring during treatment. We have already demonstrated that a Monolithic Active Pixel Sensor (MAPS)-based system can fulfill all clinical requirements except for the minimum required size. Here, we report the performance of a large-scale demonstrator system consisting of a matrix of 2 × 2 sensors, which is large enough to cover almost all radiotherapy treatment fields when affixed to the shadow tray of the LINAC head. When building a matrix structure, a small dead area is inevitable. Here, we report that with a newly developed position algorithm, leaf positions can be reconstructed over the entire range with a position resolution of below ∼200 μm in the centre of the sensor, which worsens to just below 300 μm in the middle of the gap between two sensors. A leaf position resolution below 300 μm results in a dose error below 2%, which is good enough for clinical deployment.
published_date	2023-02-06T08:35:14Z
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Performance of a Full-Scale Upstream MAPS-Based Verification Device for Radiotherapy

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