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The Role of Adipocytes in the Ovarian Cancer Metastatic Niche / Mike Williams

Swansea University Author: Mike Williams

  • E-Thesis – open access under embargo until: 21st May 2026

DOI (Published version): 10.23889/SUthesis.66574

Abstract

Ovarian cancer is characterised by metastasis to the adipocyte-rich omentum and the development of resistance to chemotherapy. Adipocytes within the omentum may play an important role in promoting ovarian cancer growth and metastasis. The ovarian cancer metastatic microenvironment is highly inflamed...

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Published: Swansea, Wales, UK 2024
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Gonzalez, Deyarina
URI: https://cronfa.swan.ac.uk/Record/cronfa66574
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first_indexed 2024-06-03T11:56:10Z
last_indexed 2024-06-03T11:56:10Z
id cronfa66574
recordtype RisThesis
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spelling v2 66574 2024-06-03 The Role of Adipocytes in the Ovarian Cancer Metastatic Niche 1f7ef84712ed671b054f2b00e27cd7cf Mike Williams Mike Williams true false 2024-06-03 MEDS Ovarian cancer is characterised by metastasis to the adipocyte-rich omentum and the development of resistance to chemotherapy. Adipocytes within the omentum may play an important role in promoting ovarian cancer growth and metastasis. The ovarian cancer metastatic microenvironment is highly inflamed, and an inflammatory environment is associated with aggressive disease and poor outcomes. In vitro models which incorporate multiple elements of the tumour microenvironment can be used to explore interactions between cancer cells and non-malignant cells within the metastatic niche and understand the contribution of inflammatory signalling to cancer progression. E-Thesis Swansea, Wales, UK Ovarian Cancer, Tumour Microenvironment, Adipocytes, In Vitro Models 21 5 2024 2024-05-21 10.23889/SUthesis.66574 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Gonzalez, Deyarina Doctoral Ph.D Swansea University Strategic Partnership Research Grant Swansea University Strategic Partnership Research Grant 2024-06-03T13:13:24.2620749 2024-06-03T12:53:19.4260987 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Mike Williams 1 Under embargo Under embargo 2024-06-03T13:03:33.7761937 Output 7690121 application/pdf E-Thesis – open access true 2026-05-21T00:00:00.0000000 Copyright: The author, Michael Ellis Williams, 2024. true eng
title The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
spellingShingle The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
Mike Williams
title_short The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
title_full The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
title_fullStr The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
title_full_unstemmed The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
title_sort The Role of Adipocytes in the Ovarian Cancer Metastatic Niche
author_id_str_mv 1f7ef84712ed671b054f2b00e27cd7cf
author_id_fullname_str_mv 1f7ef84712ed671b054f2b00e27cd7cf_***_Mike Williams
author Mike Williams
author2 Mike Williams
format E-Thesis
publishDate 2024
institution Swansea University
doi_str_mv 10.23889/SUthesis.66574
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description Ovarian cancer is characterised by metastasis to the adipocyte-rich omentum and the development of resistance to chemotherapy. Adipocytes within the omentum may play an important role in promoting ovarian cancer growth and metastasis. The ovarian cancer metastatic microenvironment is highly inflamed, and an inflammatory environment is associated with aggressive disease and poor outcomes. In vitro models which incorporate multiple elements of the tumour microenvironment can be used to explore interactions between cancer cells and non-malignant cells within the metastatic niche and understand the contribution of inflammatory signalling to cancer progression.
published_date 2024-05-21T13:13:23Z
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score 11.013731

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