E-Thesis 39 views
The Role of Adipocytes in the Ovarian Cancer Metastatic Niche / Mike Williams
Swansea University Author: Mike Williams
DOI (Published version): 10.23889/SUthesis.66574
Abstract
Ovarian cancer is characterised by metastasis to the adipocyte-rich omentum and the development of resistance to chemotherapy. Adipocytes within the omentum may play an important role in promoting ovarian cancer growth and metastasis. The ovarian cancer metastatic microenvironment is highly inflamed...
| Published: |
Swansea, Wales, UK
2024
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| Institution: | Swansea University |
| Degree level: | Doctoral |
| Degree name: | Ph.D |
| Supervisor: | Gonzalez, Deyarina |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa66574 |
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| Abstract: |
Ovarian cancer is characterised by metastasis to the adipocyte-rich omentum and the development of resistance to chemotherapy. Adipocytes within the omentum may play an important role in promoting ovarian cancer growth and metastasis. The ovarian cancer metastatic microenvironment is highly inflamed, and an inflammatory environment is associated with aggressive disease and poor outcomes. In vitro models which incorporate multiple elements of the tumour microenvironment can be used to explore interactions between cancer cells and non-malignant cells within the metastatic niche and understand the contribution of inflammatory signalling to cancer progression. |
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| Keywords: |
Ovarian Cancer, Tumour Microenvironment, Adipocytes, In Vitro Models |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Swansea University Strategic Partnership Research Grant |