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Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions
,
Conor De Barra,
Benjamin Jenkins,
Simon O’Shaughnessy,
Odhrán K. Ryan ,
Chloe McKenna ,
Helen M. Heneghan ,
Fiona Walsh ,
David K. Finlay ,
Linda V. Sinclair ,
Nick Jones ,
Daniel T. Leung ,
Donal O’Shea,
Andrew E. Hogan
The Journal of Immunology, Volume: 212, Issue: 11, Pages: 1706 - 1713
Swansea University Authors:
Benjamin Jenkins, Nick Jones
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Copyright © 2024 by The American Association of Immunologists, Inc.
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DOI (Published version): 10.4049/jimmunol.2300649
Abstract
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine producti...
| Published in: | The Journal of Immunology |
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| ISSN: | 0022-1767 1550-6606 |
| Published: |
The American Association of Immunologists
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa66067 |
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| Abstract: |
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production. The metabolic and nutritional requirements for optimal MAIT cell effector responses are still emerging. Iron is an important micronutrient and is essential for cellular fitness, in particular cellular metabolism. Iron is also critical for many pathogenic microbes, including those that activate MAIT cells. However, iron has not been investigated with respect to MAIT cell metabolic or functional responses. In this study, we show that human MAIT cells require exogenous iron, transported via CD71 for optimal metabolic activity in MAIT cells, including their production of ATP. We demonstrate that restricting iron availability by either chelating environmental iron or blocking CD71 on MAIT cells results in impaired cytokine production and proliferation. These data collectively highlight the importance of a CD71-iron axis for human MAIT cell metabolism and functionality, an axis that may have implications in conditions where iron availability is limited. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
11 |
| Start Page: |
1706 |
| End Page: |
1713 |