A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch

Hatam, Sara; Scully, Sean; Cook, Sarah; Evans, Hywel Turner; Hume, Alastair; Kallis, Constantinos; Farr, Ian; Orton, Chris; Sheikh, Aziz; Quint, Jennifer

doi:10.2147/clep.s437937

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A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD)...

Sara Hatam, Sean Scully, Sarah Cook

, Hywel Turner Evans

, Alastair Hume

, Constantinos Kallis, Ian Farr, Chris Orton

, Aziz Sheikh, Jennifer Quint

Clinical Epidemiology, Volume: 16, Pages: 235 - 247

Swansea University Authors: Sean Scully, Hywel Turner Evans , Ian Farr, Chris Orton

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DOI (Published version): 10.2147/clep.s437937

Abstract

Background: Electronic healthcare records (EHRs) are an important resource for health research that can be used to improve patient outcomes in chronic respiratory diseases. However, consistent approaches in the analysis of these datasets are needed for coherent messaging, and when undertaking compar...

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Published in:	Clinical Epidemiology
ISSN:	1179-1349
Published:	Informa UK Limited 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa66035
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first_indexed	2024-04-11T10:13:49Z
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spelling	v2 66035 2024-04-11 A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch 7d578c07f0f506fa6e2255af54555ddc Sean Scully Sean Scully true false 73cc98a5b8e4122fdfcee5d88208b0b7 0000-0001-6745-4187 Hywel Turner Evans Hywel Turner Evans true false 3c02e7e9c2b064ee3e96e83b9777dde4 Ian Farr Ian Farr true false 555c622e1f7bd9d2e0341f2ebbfd3e7f 0000-0002-9561-2493 Chris Orton Chris Orton true false 2024-04-11 HDAT Background: Electronic healthcare records (EHRs) are an important resource for health research that can be used to improve patient outcomes in chronic respiratory diseases. However, consistent approaches in the analysis of these datasets are needed for coherent messaging, and when undertaking comparative studies across different populations.Methods and results: We developed a harmonised curation approach to generate comparable patient cohorts for asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) using datasets from within Clinical Practice Research Datalink (CPRD; for England), Secure Anonymised Information Linkage (SAIL; for Wales) and DataLoch (for Scotland) by defining commonly derived variables consistently between the datasets. By working in parallel on the curation methodology used for CPRD, SAIL and DataLoch for asthma, COPD and ILD, we were able to highlight key differences in coding and recording between the databases and identify solutions to enable valid comparisons.Conclusion: Codelists and metadata generated have been made available to help re-create the asthma, COPD and ILD cohorts in CPRD, SAIL and DataLoch for different time periods, and provide a starting point for the curation of respiratory datasets in other EHR databases, expediting further comparable respiratory research. Journal Article Clinical Epidemiology 16 235 247 Informa UK Limited 1179-1349 COPD, asthma, ILD, HER, harmonisation, data curation 4 4 2024 2024-04-04 10.2147/clep.s437937 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University Another institution paid the OA fee This work is supported by BREATHE-The Health Data Research Hub for Respiratory Health (MC_PC_19004). BREATHE is funded through the UK Research and Innovation Industrial Strategy Challenge Fund with additional support from the Medical Research Council and delivered through Health Data Research UK. Infrastructure support for this research was provided by the NIHR Imperial Biomedical Research Centre (BRC). 2024-04-11T12:25:03.5412400 2024-04-11T11:09:03.9025699 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Sara Hatam 1 Sean Scully 2 Sarah Cook 0000-0003-1250-2967 3 Hywel Turner Evans 0000-0001-6745-4187 4 Alastair Hume 0000-0001-8322-9182 5 Constantinos Kallis 6 Ian Farr 7 Chris Orton 0000-0002-9561-2493 8 Aziz Sheikh 9 Jennifer Quint 0000-0003-0149-4869 10 66035__29988__7d1eb534405e4c55941bc7e0176bd880.pdf 66035.VOR.pdf 2024-04-11T12:23:30.9460068 Output 2486322 application/pdf Version of Record true © 2024 Hatam et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
spellingShingle	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch Sean Scully Hywel Turner Evans Ian Farr Chris Orton
title_short	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
title_full	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
title_fullStr	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
title_full_unstemmed	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
title_sort	A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD), Secure Anonymised Information Linkage (SAIL) Databank and DataLoch
author_id_str_mv	7d578c07f0f506fa6e2255af54555ddc 73cc98a5b8e4122fdfcee5d88208b0b7 3c02e7e9c2b064ee3e96e83b9777dde4 555c622e1f7bd9d2e0341f2ebbfd3e7f
author_id_fullname_str_mv	7d578c07f0f506fa6e2255af54555ddc_*_Sean Scully 73cc98a5b8e4122fdfcee5d88208b0b7__Hywel Turner Evans 3c02e7e9c2b064ee3e96e83b9777dde4__Ian Farr 555c622e1f7bd9d2e0341f2ebbfd3e7f_*_Chris Orton
author	Sean Scully Hywel Turner Evans Ian Farr Chris Orton
author2	Sara Hatam Sean Scully Sarah Cook Hywel Turner Evans Alastair Hume Constantinos Kallis Ian Farr Chris Orton Aziz Sheikh Jennifer Quint
format	Journal article
container_title	Clinical Epidemiology
container_volume	16
container_start_page	235
publishDate	2024
institution	Swansea University
issn	1179-1349
doi_str_mv	10.2147/clep.s437937
publisher	Informa UK Limited
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
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description	Background: Electronic healthcare records (EHRs) are an important resource for health research that can be used to improve patient outcomes in chronic respiratory diseases. However, consistent approaches in the analysis of these datasets are needed for coherent messaging, and when undertaking comparative studies across different populations.Methods and results: We developed a harmonised curation approach to generate comparable patient cohorts for asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) using datasets from within Clinical Practice Research Datalink (CPRD; for England), Secure Anonymised Information Linkage (SAIL; for Wales) and DataLoch (for Scotland) by defining commonly derived variables consistently between the datasets. By working in parallel on the curation methodology used for CPRD, SAIL and DataLoch for asthma, COPD and ILD, we were able to highlight key differences in coding and recording between the databases and identify solutions to enable valid comparisons.Conclusion: Codelists and metadata generated have been made available to help re-create the asthma, COPD and ILD cohorts in CPRD, SAIL and DataLoch for different time periods, and provide a starting point for the curation of respiratory datasets in other EHR databases, expediting further comparable respiratory research.
published_date	2024-04-04T12:25:00Z
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A Harmonised Approach to Curating Research-Ready Datasets for Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD) in England, Wales and Scotland Using Clinical Practice Research Datalink (CPRD)...

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