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Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds

Matt Bedding, Nava Khatri, Perumal Nithiarasu Orcid Logo, Bjornar Sandnes Orcid Logo, Paul Egan, Feihu Zhao Orcid Logo

Journal of Engineering Design, Pages: 1 - 15

Swansea University Authors: Matt Bedding, Perumal Nithiarasu Orcid Logo, Bjornar Sandnes Orcid Logo, Feihu Zhao Orcid Logo

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DOI (Published version): 10.1080/09544828.2024.2321224

Abstract

It is commonly known that mechanical stimulation, for example, wall shear stress (WSS), can affect cellular behaviours. In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing...

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Published in: Journal of Engineering Design
ISSN: 0954-4828 1466-1837
Published: Informa UK Limited 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65980
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In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing and facilitating the micro-physical/chemical environment on cells during 3-dimensional (3D) cell culturing. It is known that scaffold porous geometries influence scaffold permeability and internal WSS. Computational simulations are commonly employed to determine the WSS; however, these simulations can be computationally expensive and may not be readily accessible to everyone due to a knowledge gap. To address this limitation, this study proposes an empirical equation for calculating the scaffold permeability based on the Kozeny-Carman equation. The new equation considers the porous geometric features, providing an accurate estimation of the scaffold permeability. Furthermore, the study introduces a new correlation between WSS and permeability, aiming to establish an efficient and precise estimation of internal WSS. This correlation enables efficient estimation of the WSS within porous scaffolds without relying on computationally demanding simulations. Therefore, the output from this study can negate the issues of using computational simulation for determining scaffold permeability and internal WSS under perfusion flow by providing empirical equations.</abstract><type>Journal Article</type><journal>Journal of Engineering Design</journal><volume>0</volume><journalNumber/><paginationStart>1</paginationStart><paginationEnd>15</paginationEnd><publisher>Informa UK Limited</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0954-4828</issnPrint><issnElectronic>1466-1837</issnElectronic><keywords>TPMS scaffold permeability; empirical model; perfusion bioreactor; wall shear stress</keywords><publishedDay>3</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-04-03</publishedDate><doi>10.1080/09544828.2024.2321224</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>This study was supported by Royal Society Research Grant (reference code: RGS\R2\212280). MBT was funded by EPSRC-DTP scholarship (reference code: EP/T517987/1 - 2573181).</funders><projectreference/><lastEdited>2024-10-17T15:00:26.7924256</lastEdited><Created>2024-04-08T12:03:56.0249634</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Matt</firstname><surname>Bedding</surname><order>1</order></author><author><firstname>Nava</firstname><surname>Khatri</surname><order>2</order></author><author><firstname>Perumal</firstname><surname>Nithiarasu</surname><orcid>0000-0002-4901-2980</orcid><order>3</order></author><author><firstname>Bjornar</firstname><surname>Sandnes</surname><orcid>0000-0002-4854-5857</orcid><order>4</order></author><author><firstname>Paul</firstname><surname>Egan</surname><order>5</order></author><author><firstname>Feihu</firstname><surname>Zhao</surname><orcid>0000-0003-0515-6808</orcid><order>6</order></author></authors><documents><document><filename>65980__30470__6753c257661d43148c0db9c1f6198c6f.pdf</filename><originalFilename>65980.VoR.pdf</originalFilename><uploaded>2024-05-28T16:24:18.5127715</uploaded><type>Output</type><contentLength>4819715</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2024 The Author(s). 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spelling v2 65980 2024-04-08 Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds d44c21114186f602f81db0dd1280b99d Matt Bedding Matt Bedding true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 61c7c04b5c804d9402caf4881e85234b 0000-0002-4854-5857 Bjornar Sandnes Bjornar Sandnes true false 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2024-04-08 It is commonly known that mechanical stimulation, for example, wall shear stress (WSS), can affect cellular behaviours. In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing and facilitating the micro-physical/chemical environment on cells during 3-dimensional (3D) cell culturing. It is known that scaffold porous geometries influence scaffold permeability and internal WSS. Computational simulations are commonly employed to determine the WSS; however, these simulations can be computationally expensive and may not be readily accessible to everyone due to a knowledge gap. To address this limitation, this study proposes an empirical equation for calculating the scaffold permeability based on the Kozeny-Carman equation. The new equation considers the porous geometric features, providing an accurate estimation of the scaffold permeability. Furthermore, the study introduces a new correlation between WSS and permeability, aiming to establish an efficient and precise estimation of internal WSS. This correlation enables efficient estimation of the WSS within porous scaffolds without relying on computationally demanding simulations. Therefore, the output from this study can negate the issues of using computational simulation for determining scaffold permeability and internal WSS under perfusion flow by providing empirical equations. Journal Article Journal of Engineering Design 0 1 15 Informa UK Limited 0954-4828 1466-1837 TPMS scaffold permeability; empirical model; perfusion bioreactor; wall shear stress 3 4 2024 2024-04-03 10.1080/09544828.2024.2321224 COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) This study was supported by Royal Society Research Grant (reference code: RGS\R2\212280). MBT was funded by EPSRC-DTP scholarship (reference code: EP/T517987/1 - 2573181). 2024-10-17T15:00:26.7924256 2024-04-08T12:03:56.0249634 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Matt Bedding 1 Nava Khatri 2 Perumal Nithiarasu 0000-0002-4901-2980 3 Bjornar Sandnes 0000-0002-4854-5857 4 Paul Egan 5 Feihu Zhao 0000-0003-0515-6808 6 65980__30470__6753c257661d43148c0db9c1f6198c6f.pdf 65980.VoR.pdf 2024-05-28T16:24:18.5127715 Output 4819715 application/pdf Version of Record true © 2024 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
spellingShingle Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
Matt Bedding
Perumal Nithiarasu
Bjornar Sandnes
Feihu Zhao
title_short Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
title_full Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
title_fullStr Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
title_full_unstemmed Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
title_sort Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
author_id_str_mv d44c21114186f602f81db0dd1280b99d
3b28bf59358fc2b9bd9a46897dbfc92d
61c7c04b5c804d9402caf4881e85234b
1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv d44c21114186f602f81db0dd1280b99d_***_Matt Bedding
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
61c7c04b5c804d9402caf4881e85234b_***_Bjornar Sandnes
1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Matt Bedding
Perumal Nithiarasu
Bjornar Sandnes
Feihu Zhao
author2 Matt Bedding
Nava Khatri
Perumal Nithiarasu
Bjornar Sandnes
Paul Egan
Feihu Zhao
format Journal article
container_title Journal of Engineering Design
container_volume 0
container_start_page 1
publishDate 2024
institution Swansea University
issn 0954-4828
1466-1837
doi_str_mv 10.1080/09544828.2024.2321224
publisher Informa UK Limited
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description It is commonly known that mechanical stimulation, for example, wall shear stress (WSS), can affect cellular behaviours. In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing and facilitating the micro-physical/chemical environment on cells during 3-dimensional (3D) cell culturing. It is known that scaffold porous geometries influence scaffold permeability and internal WSS. Computational simulations are commonly employed to determine the WSS; however, these simulations can be computationally expensive and may not be readily accessible to everyone due to a knowledge gap. To address this limitation, this study proposes an empirical equation for calculating the scaffold permeability based on the Kozeny-Carman equation. The new equation considers the porous geometric features, providing an accurate estimation of the scaffold permeability. Furthermore, the study introduces a new correlation between WSS and permeability, aiming to establish an efficient and precise estimation of internal WSS. This correlation enables efficient estimation of the WSS within porous scaffolds without relying on computationally demanding simulations. Therefore, the output from this study can negate the issues of using computational simulation for determining scaffold permeability and internal WSS under perfusion flow by providing empirical equations.
published_date 2024-04-03T15:00:24Z
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